Thalamus and pain.
Thalamus and pain.
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DOI：
10.1016/j.aat.2013.06.011
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发表时间：
2013-06-01
期刊：
影响因子：
--
通讯作者：
Lu, Pen-Li
中科院分区：
文献类型：
--
作者：
Yen, Chen-Tung;Lu, Pen-Li
丘脑是将伤害性信息传递到大脑皮层的关键中继站。本文综述了丘脑参与急慢性疼痛功能的输入输出连接、功能成像、直接神经元记录、刺激和损伤研究。由于丘脑与大脑皮层的特殊相互联系、强烈的伤害性反应以及其受损时的严重慢性疼痛，丘脑可能是疼痛意识的关键，也是理解慢性疼痛条件下自发性和诱发性疼痛的关键。提出了今后研究的工作计划。
The thalamus is a key relay station for the transmission of nociceptive information to the cerebral cortex. We review the input-output connection, functional imaging, direct neuronal recording, stimulation, and lesioning studies on the involvement of thalamus in acute and chronic pain functions. Based on its specific reciprocal connection with the cerebral cortex, strong nociceptive responsiveness, and the severe chronic pain when it is damaged, the thalamus may hold the key to pain consciousness and the key to understanding spontaneous and evoked pain in chronic pain conditions. A work plan is proposed for future study.