Plasmodium-specific atypical memory B cells are short-lived activated B cells.
Plasmodium-specific atypical memory B cells are short-lived activated B cells.
复制标题
DOI：
10.7554/elife.39800
复制
发表时间：
2018-11-02
期刊：
影响因子：
7.7
通讯作者：
Langhorne J
中科院分区：
文献类型：
--
作者：
Pérez-Mazliah D;Gardner PJ;Schweighoffer E;McLaughlin S;Hosking C;Tumwine I;Davis RS;Potocnik AJ;Tybulewicz VL;Langhorne J
非典型记忆B细胞的一个子集在疟疾和几种感染、自身免疫性疾病和人类和小鼠的衰老中积累。有人认为，这些细胞是耗尽的长寿记忆B细胞，它们的积累可能导致对某些慢性感染（如疟疾和艾滋病毒）的持久免疫力低下。在这里，我们产生了一个免疫球蛋白重链基因敲入小鼠与BCR识别MSP 1的啮齿类疟原虫，疟原虫夏氏。结合蚊子引起的夏氏疟原虫感染，我们发现疟原虫特异性非典型记忆B细胞是短暂的，在慢性感染自然消退后消失。这些细胞显示出活化、增殖、DNA复制和浆母细胞的特征。我们的数据表明，疟原虫特异性非典型记忆B细胞不是长寿的记忆B细胞的一个子集，而是短寿命的激活细胞，和生理持续的B细胞反应的一部分。
A subset of atypical memory B cells accumulates in malaria and several infections, autoimmune disorders and aging in both humans and mice. It has been suggested these cells are exhausted long-lived memory B cells, and their accumulation may contribute to poor acquisition of long-lasting immunity to certain chronic infections, such as malaria and HIV. Here, we generated an immunoglobulin heavy chain knock-in mouse with a BCR that recognizes MSP1 of the rodent malaria parasite, Plasmodium chabaudi. In combination with a mosquito-initiated P. chabaudi infection, we show that Plasmodium-specific atypical memory B cells are short-lived and disappear upon natural resolution of chronic infection. These cells show features of activation, proliferation, DNA replication, and plasmablasts. Our data demonstrate that Plasmodium-specific atypical memory B cells are not a subset of long-lived memory B cells, but rather short-lived activated cells, and part of a physiologic ongoing B-cell response.