Light detection in a 'blind' mammal
Light detection in a 'blind' mammal
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DOI：
10.1038/3656
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发表时间：
1998-12-01
影响因子：
25
通讯作者：
Foster, RG
中科院分区：
文献类型：
--
作者：
David-Gray, ZK;Janssen, JWH;Foster, RG
一些“失明”动物的视蛋白基因是否编码功能性光色素，如果是的话，这些光色素可能介导哪些生理反应，一直存在相当大的争论。我们报道了首次从一种视觉失明的化石哺乳动物——盲鼹鼠（Spalax ehrenbergi）高度退化的眼睛中分离并体外表达了一种功能性锥状光色素。此外，我们表明这种光色素介导光对该物种昼夜节律行为的影响。
There has been considerable debate whether the opsin genes of several'blind'animals code for functional photopigments, and if so, what physiological responses these photopigments may mediate 1. We report the first isolation and in vitro expression of a functional cone-like photopigment from the highly degenerate eye of a visually blind fossorial mammal, the blind mole rat (Spalax ehrenbergi). Furthermore, we show that this photopigment mediates the effects of light on circadian behavior in this species.