Tumour cords in 52 human bronchial and cervical squamous cell carcinomas: inferences for their cellular kinetics and radiobiology.
Tumour cords in 52 human bronchial and cervical squamous cell carcinomas: inferences for their cellular kinetics and radiobiology.
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DOI：
10.1038/bjc.1985.55
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发表时间：
1985-03
影响因子：
8.8
通讯作者：
Buckley CH
中科院分区：
文献类型：
--
作者：
Moore JV;Hasleton PS;Buckley CH
对33例支气管鳞癌(SCC)和19例宫颈鳞癌(SCC)的肿瘤索进行了测量。这两个部位的鳞状细胞癌的总体平均脊髓半径为104微米，与啮齿动物各种肿瘤的总体平均半径相似。在鳞状细胞癌的血管旁的肿瘤细胞，平均有丝分裂指数为2.1%，由此可以推测一个快速的潜在倍增时间(大约31-66小时)。宫颈鳞状细胞癌索内的死亡细胞比例高于动物肿瘤。使用脐带半径的测量值和已发表的描述新陈代谢组织中氧气扩散和消耗的方程，试图计算这些鳞状细胞癌脐带血管中的氧分压。
Tumour cords have been measured in 33 cases of squamous cell carcinoma (SCC) of the bronchus and 19 cases of SCC of the uterine cervix. The overall mean cord radius for SCC in both sites was 104 microns, similar to the overall mean for various tumours in rodents. For tumour cells adjacent to blood vessels in cords of SCC, the mean Mitotic Index was 2.1% and from this value a rapid potential doubling time could be inferred (approximately 31 to 66 h). The proportion of dead cells within cords of cervical SCC was higher than in animal tumours. Using measured values for cord radius and published equations that describe the diffusion and consumption of oxygen in metabolising tissue, an attempt was made to calculate the oxygen partial pressure in vessels of cords of these SCC.