Polyfunctionalised Nanoparticles Bearing Robust Gadolinium Surface Units for High Relaxivity Performance in MRI
Polyfunctionalised Nanoparticles Bearing Robust Gadolinium Surface Units for High Relaxivity Performance in MRI
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DOI：
10.1002/chem.201901820
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发表时间：
2019-07-17
影响因子：
4.3
通讯作者：
Wilton-Ely, James D. E. T.
中科院分区：
文献类型：
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作者：
Chabloz, Nicolas G.;Wenzel, Margot N.;Wilton-Ely, James D. E. T.
基于DO 3A（水合数q=1）的具有二硫代氨基甲酸酯系链的八齿钆单元的第一个实例已经被设计并附着到金纳米颗粒（直径约4.4 nm）的表面。除了这种附着的上级稳健性之外，Gd络合物在纳米颗粒表面上的受限旋转导致弛豫率（r（1））从未结合形式的4.0 mm（-1）s（-1）急剧增加到34.3 mm（-1）s（-1）。（在10 MHz，37 ℃）和22 +/- 2 mm（-1）s（-1）（在63.87 MHz，25 ℃）。一锅法合成路线提供了一种制备一系列多功能金纳米颗粒的简单而通用的方法。用于生物相容性（PEG和硫代葡萄糖单元）和靶向（叶酸）的额外表面单元的并入导致对这些无毒多功能材料观察到的高弛豫性的几乎没有不利影响。除了归因于金纳米颗粒的被动靶向之外，包含能够靶向由癌细胞（例如HeLa细胞）过表达的叶酸受体的单元，说明了这些组件的潜力。
The first example of an octadentate gadolinium unit based on DO3A (hydration number q=1) with a dithiocarbamate tether has been designed and attached to the surface of gold nanoparticles (around 4.4 nm in diameter). In addition to the superior robustness of this attachment, the restricted rotation of the Gd complex on the nanoparticle surface leads to a dramatic increase in relaxivity (r(1)) from 4.0 mm(-1) s(-1) in unbound form to 34.3 mm(-1) s(-1) (at 10 MHz, 37 degrees C) and 22 +/- 2 mm(-1) s(-1) (at 63.87 MHz, 25 degrees C) when immobilised on the surface. The one-pot synthetic route provides a straightforward and versatile way of preparing a range of multifunctional gold nanoparticles. The incorporation of additional surface units for biocompatibility (PEG and thioglucose units) and targeting (folic acid) leads to little detrimental effect on the high relaxivity observed for these non-toxic multifunctional materials. In addition to the passive targeting attributed to gold nanoparticles, the inclusion of a unit capable of targeting the folate receptors overexpressed by cancer cells, such as HeLa cells, illustrates the potential of these assemblies.