Specialized pro-resolving mediators: It’s anti-oxidant stress role in multiple disease models
Specialized pro-resolving mediators: It’s anti-oxidant stress role in multiple disease models
复制标题
专门的促解决介质：它在多种疾病模型中的抗氧化应激作用
DOI：
10.1016/j.molimm.2020.07.017
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发表时间：
2020
影响因子：
3.6
通讯作者：
Shanglong Yao
中科院分区：
文献类型：
--
作者：
Fuquan Wang;Shiqian Huang;Haifa Xia;Shanglong Yao
氧化应激相关损伤是机体内环境中氧化与抗氧化作用失衡所导致的一种负性状态。氧化应激已被证实是衰老和多种疾病的重要因素，抑制不适当的氧化应激反应对于维持正常的生理功能是重要的。最近，相当多的注意力集中在专门的亲解决调解员（SPM）。SPMs是一种来源于多不饱和脂肪酸的内源性介质，具有抗炎、促消退、促进组织损伤修复等多种保护作用。SPMs对氧化应激的作用已被广泛研究，并提供了一种可能的治疗方法。本文综述了SPMs在氧化应激相关疾病中的积极作用及其可能的作用机制，为进一步认识SPMs在氧化应激中的作用提供理论支持，为寻找氧化应激相关疾病的治疗靶点提供理论依据。
Oxidative stress-related injury is a negative state caused by the imbalance between oxidation and antioxidant effects in the internal environment of the body. Oxidative stress has been confirmed to be an important factor in aging and a variety of diseases and the inhibition of inappropriate oxidative stress responses are important for maintaining normal physiological functions. Recently, considerable attention has been focused on specialized pro-resolving mediators(SPMs). SPMs are endogenous mediators derived from polyunsaturated fatty acids, which have multiple protective effects such as anti-inflammation, pro-resolution, and promoting tissue damage repair, etc. Moreover, the role of SPMs on oxidative stress has been extensively researched and provides a possible treatment method. In the current study, we review the positive role of SPMs in oxidative stress-related disease and outline the possible involved mechanism, thus providing the theoretical support for a better understanding of the roles of SPMs in oxidative stress and the theoretical basis for finding targets for the oxidative stress-related diseases.