A prospective 5-year follow-up study on the behavioral disturbances of community-dwelling elderly people with Alzheimer disease
A prospective 5-year follow-up study on the behavioral disturbances of community-dwelling elderly people with Alzheimer disease
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DOI：
10.1097/00002093-199910000-00005
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发表时间：
1999-10-01
影响因子：
2.1
通讯作者：
Kakuma, T
中科院分区：
文献类型：
--
作者：
Asada, T;Kinoshita, T;Kakuma, T
本研究的目的是确定行为障碍的纵向过程，并检查这些障碍是否是阶段依赖性的阿尔茨海默病（AD）的过程中。107个社区居住的可能AD患者进行了评估，每年6次，使用一个有效的和可靠的评级量表，麻烦的行为量表，评估行为障碍的频率。根据临床痴呆评定（CDR; 1 =轻度，2 =中度，3 =重度）评估的基线整体功能，将受试者分为三组。在5年的观察期结束时，31名受试者仍然是积极的参与者，52名死亡，20名住在机构，4名停止参与。他们的行为障碍变化模式在很大程度上取决于疾病的基线严重程度。行为障碍频率一般在CDR 2阶段达到峰值，此后呈下降趋势。在疾病的过程中，干扰频率的个体差异很大。了解AD的行为过程将使临床医生能够更好地为家庭提供咨询，并评估行为症状治疗的结果。
The aim of the present study was to determine the longitudinal course of behavioral disturbances and to examine whether these disturbances are stage dependent during the course of Alzheimer disease (AD). One hundred seven community-dwelling patients with probable AD were assessed up to six times annually by using a validated and reliable rating scale, the Troublesome Behavior Scale, for assessing the frequencies of behavioral disturbances. The subjects were divided into three groups according to their baseline global function as assessed by the Clinical Dementia Rating (CDR; 1 = mild, 2 = moderate, 3 = severe). At the end of the 5-year observation period, 3 1 subjects were still active participants, 52 had died, 20 lived in institutions, and 4 had stopped participating. The patterns of their behavioral disturbance changes depended to a considerable extent on the baseline severity of the illness. The behavioral disturbance frequencies generally peaked at the CDR 2 stage and followed a downward trend thereafter. Considerable individual variations in the disturbance frequencies during the course of the illness were observed. Knowing the behavioral course of AD will enable clinicians to better counsel families and appraise the results of treatments for behavioral symptoms.