Amino acid regulation of gene expression
Amino acid regulation of gene expression
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DOI：
10.1093/jn/131.9.2460s
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发表时间：
2001-09-01
影响因子：
4.2
通讯作者：
Kimball, SR
中科院分区：
文献类型：
--
作者：
Jefferson, LS;Kimball, SR
氨基酸对基因表达的调节是通过多种影响 DNA 转录和 mRNA 翻译的机制介导的。本报告回顾了最近的研究结果，证明氨基酸在调节 mRNA 翻译起始阶段中的作用。该报告重点关注翻译起始中的关键调控事件，并讨论了细胞内传递氨基酸充足或缺乏的一些信号传导途径。最后，它考虑了这个快速发展的研究领域中一些尚未解答的重要问题。
Regulation of gene expression by amino acids is mediated through a number of mechanisms affecting both the transcription of DNA and the translation of mRNA. This report reviews recent findings demonstrating a role for amino acids in regulating the initiation phase of mRNA translation. The report focuses on key regulatory events in translation initiation and discusses some of the signaling pathways through which amino acid sufficiency or the lack thereof is communicated within the cell. It concludes with a consideration of some of the important unanswered questions in this rapidly advancing area of research.