Effects of prolonged L-carnitine administration on delayed muscle pain and CK release after eccentric effort
Effects of prolonged L-carnitine administration on delayed muscle pain and CK release after eccentric effort
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DOI：
10.1055/s-2007-972854
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发表时间：
1996-07-01
影响因子：
2.5
通讯作者：
Vecchiet, L
中科院分区：
文献类型：
--
作者：
Giamberardino, MA;Dragani, L;Vecchiet, L
偏心肌肉努力是已知的诱导迟发性肌肉酸痛（DOMS）和肌肉损伤，这是不响应的药物治疗与最常见的镇痛剂。本研究的目的是调查口服L-肉毒碱补充剂对疼痛（VAS量表），压痛（疼痛阈值）和CK释放引起的20分钟离心努力的四头肌的影响。对6名未经训练的受试者进行了单盲研究（平均年龄：26 +/-3.8岁;平均身高：173 +/-4.6cm;平均体重：68.3 +/-4.5kg），在此期间，每个受试者：a）给予3 g/天的安慰剂3周，间隔一周后，给予3 g/天的L-肉碱3周; B）在第3周和第7周的第一天进行2次台阶测试，颠倒运动肢体的顺序。在8个月后进行的一组单独的实验中，还在相同的受试者中研究了训练对疼痛参数和CK水平的可能影响，这些受试者在没有药物的情况下以4周的间隔进行2步测试。与安慰剂相比，L-肉毒碱显著降低了疼痛、压痛和CK释放。相比之下，在没有药物的情况下进行的蜂巢试验之间测量的参数没有发现显著差异。它的结论是，L-肉毒碱具有保护作用，对疼痛和损害离心努力。这种作用主要归因于化合物的血管舒张性质，其既改善缺氧/受损肌肉的能量代谢，又增强致痛代谢物的洗脱。
Eccentric muscle effort is known to induce delayed muscle soreness (DOMS) and muscle damage which are not responsive to medical treatment with the most common analgesic agents. The aim of the study was to investigate the effects of oral L-carnitine supplementation on pain (VAS scale), tenderness (pain thresholds) and CK release induced by a 20-min eccentric effort of the quadriceps muscle. A single-blind study was carried out on 6 untrained subjects (mean age: 26 +/- 3.8 yrs; mean height: 173 +/- 4.6 cm: mean body weight, 68.3 +/- 4.5 kg) over 7 weeks during which each subject: a) was given 3 g/day of placebo for 3 weeks and, after a week's interval, 3 g/day of L-carnitine for 3 weeks; b) performed 2 step tests on the first day of the 3rd and 7th week inverting the order of the;exercising limb. In a separate set of experiments carried out 8 months later, the possible effects of training on pain parameters and CK levels were also investigated in the same subjects who performed 2 step tests at a 4-weeks' interval, without medication. L-carnitine significantly reduced pain, tenderness and CK release after the effort with respect to placebo, In contrast, no significant difference was found in the parameters measured between the hive tests performed without medication. It is concluded that L-carnitine has a protective effect against-pain and damage from eccentric effort. This effect is mainly attributed to the vasodilation property of the compound,which both improves energetic metabolism of the hypoxic/damaged muscle and enhances wash-out of algogenic metabolites.