Relationship between matrix metalloproteinases and the occurrence and development of ovarian cancer.
Relationship between matrix metalloproteinases and the occurrence and development of ovarian cancer.
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基质金属蛋白酶与卵巢癌发生发展的关系
DOI：
10.1590/1414-431x20176104
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发表时间：
2017-05-18
期刊：
影响因子：
--
通讯作者：
Chen Q
中科院分区：
文献类型：
--
作者：
Zhang Y;Chen Q
Ovarian cancer is one of the most malignant genital cancers, with a high mortality rate. Many researchers have suggested that matrix metalloproteinases (MMPs) have remarkably high expression in ovarian cancer tissues. MMPs are considered to be related to the occurrence, development, invasion and metastasis of ovarian cancer. Moreover, some studies have discovered that the unbalance between MMPs and tissue inhibitor of metalloproteinases (TIMPs) are associated with the malignant phenotype of tumors. This review summarizes the latest research progress of MMPs in ovarian cancer. The investigation of MMP mechanism in ovarian cancer will facilitate the development of effective anti-tumor drugs, and thereby improve the survival rate of patients with ovarian cancer.
