IMPAIRED SYMPATHETIC NERVOUS-SYSTEM RESPONSE TO COGNITIVE EFFORT IN EARLY ALZHEIMERS-DISEASE
IMPAIRED SYMPATHETIC NERVOUS-SYSTEM RESPONSE TO COGNITIVE EFFORT IN EARLY ALZHEIMERS-DISEASE
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DOI：
10.1093/geronj/44.1.m8
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发表时间：
1989-01-01
期刊：
影响因子：
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通讯作者：
RASKIND, MA
中科院分区：
文献类型：
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作者：
BORSON, S;BARNES, RF;RASKIND, MA
在10名早期阿尔茨海默病患者和一组健康老年人中比较了交感神经系统对认知挑战和生理刺激（直立姿势）的反应。血浆儿茶酚胺和心血管反应直立姿势在两组相似。然而，在精神努力的交感神经激活受损的患者组，这种差异似乎并不归因于动机因素。阿尔茨海默氏病与交感神经系统功能缺陷有关，交感神经系统功能缺陷与认知努力特别相关，并在疾病过程的早期出现。
Sympathetic nervous system responses to a cognitive challenge and a physiologic stimulus (upright posture) were compared in 10 patients with early Alzheimer''s Disease and a group of healthy older adults. Plasma catecholamine and cardiovascular responses to upright posture were similar in the two groups. However, sympathetic activation during mental effort was impaired in the patient group; this difference did not appear to be attributable to motivational factors. Alzheimer''s Disease is associated with a defect in sympathetic nervous system function that is specifically linked to cognitive effort and appears early in the course of the disease.