Integrins and the actin cytoskeleton
Integrins and the actin cytoskeleton
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DOI：
10.1016/j.ceb.2006.12.013
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发表时间：
2007-02-01
影响因子：
7.5
通讯作者：
Brown, Nicholas H.
中科院分区：
文献类型：
--
作者：
Delon, Isabelle;Brown, Nicholas H.
连接肌动蛋白细胞骨架的能力是整合素粘附功能的关键部分。整合素和细胞骨架之间的这种联系涉及整合素相关蛋白的大型复合体，该复合体在连接的组装和拆卸中都起作用。遗传证据有助于澄清这种联系的不同组成部分的相对贡献。在不同情况下，整合素可以刺激或抑制基于肌动蛋白的结构，这表明从整合素到细胞骨架的途径多种多样。细胞骨架也有助于整合素连接的程度，使粘合接触获得足够的强度来抵抗参与细胞运动和功能的收缩力。
The ability to connect to the actin cytoskeleton is a key part of the adhesive function of integrins. This linkage between integrins and the cytoskeleton involves a large complex of integrin-associated proteins that function in both the assembly and disassembly of the link. Genetic evidence has helped to clarify the relative contributions of different components of this link. In different contexts integrins can either stimulate or suppress actin based structures, indicating the variety of pathways leading from integrins to the cytoskeleton. The cytoskeleton also contributes to the extent of the integrin junction, allowing an adhesive contact to attain sufficient strength to resist contractile forces involved in cellular movement and function.