Highly Stretchable Hydrogels as Wearable and Implantable Sensors for Recording Physiological and Brain Neural Signals.
Highly Stretchable Hydrogels as Wearable and Implantable Sensors for Recording Physiological and Brain Neural Signals.
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DOI：
10.1002/advs.202201059
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发表时间：
2022-05
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记录脑神经信号等电生理信息在健康监测和疾病诊断中具有重要意义。然而，随着时间的推移，异物反应和性能损失是由传感器和组织之间的化学机械失配引起的主要挑战。在这里，微凝胶被用作水凝胶网络中的大的交联中心，以调节模数和抗疲劳性/伸长性之间的权衡，从而产生与神经组织的化学机械性能非常匹配的水凝胶。与纳米颗粒增强的水凝胶相比，该水凝胶表现出显著不同的特性。该水凝胶具有较低的模数、良好的延伸性和优异的抗疲劳性能。结果表明，这种水凝胶非常适合制成可穿戴和可植入的传感器，这种传感器可以获取生理压力信号，记录大鼠脑内的局部场电位，并通过损伤的大鼠周围神经传递信号。这种水凝胶表现出与组织良好的化学机械匹配、可忽略的异物反应以及延长时间内最小的信号衰减，因此被成功地用作长期植入性传感装置。这项工作有助于加深对生物杂交界面的理解，同时也为高效获取生理信息的植入式神经探针提供了技术设计理念。提出了一种利用微凝胶作为水凝胶网络中大的交联中心来调节模数和抗疲劳/伸长性之间的权衡的策略。所制备的水凝胶可用于获取生理信号，记录大脑局部场电位，并通过受损的周围神经传递信号。适当的性能使得异物响应和信号随时间的衰减可以忽略不计。
Recording electrophysiological information such as brain neural signals is of great importance in health monitoring and disease diagnosis. However, foreign body response and performance loss over time are major challenges stemming from the chemomechanical mismatch between sensors and tissues. Herein, microgels are utilized as large crosslinking centers in hydrogel networks to modulate the tradeoff between modulus and fatigue resistance/stretchability for producing hydrogels that closely match chemomechanical properties of neural tissues. The hydrogels exhibit notably different characteristics compared to nanoparticles reinforced hydrogels. The hydrogels exhibit relatively low modulus, good stretchability, and outstanding fatigue resistance. It is demonstrated that the hydrogels are well suited for fashioning into wearable and implantable sensors that can obtain physiological pressure signals, record the local field potentials in rat brains, and transmit signals through the injured peripheral nerves of rats. The hydrogels exhibit good chemomechanical match to tissues, negligible foreign body response, and minimal signal attenuation over an extended time, and as such is successfully demonstrated for use as long‐term implantable sensory devices. This work facilitates a deeper understanding of biohybrid interfaces, while also advancing the technical design concepts for implantable neural probes that efficiently obtain physiological information. A strategy is proposed using microgels as large crosslinking centers in hydrogel networks to modulate the tradeoff between modulus and fatigue resistance/stretchability. The prepared hydrogels can be used to obtain physiological signals, record the local field potentials in brains, and transmit signals through injured peripheral nerves. The appropriate performances lead to negligible foreign body response and signal attenuation with time.