Hybrid Materials: Theranostic USPIO‐Loaded Microbubbles for Mediating and Monitoring Blood‐Brain Barrier Permeation (Adv. Funct. Mater. 1/2015)
Hybrid Materials: Theranostic USPIO‐Loaded Microbubbles for Mediating and Monitoring Blood‐Brain Barrier Permeation (Adv. Funct. Mater. 1/2015)
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DOI：
10.1002/adfm.201570002
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发表时间：
2015
影响因子：
19
通讯作者：
T. Lammers;Patrick Koczera;S. Fokong;F. Gremse;J. Ehling;M. Vogt;A. Pich;G. Storm;M. Zandvoort;F. Kiessling
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文献类型：
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作者：
T. Lammers;Patrick Koczera;S. Fokong;F. Gremse;J. Ehling;M. Vogt;A. Pich;G. Storm;M. Zandvoort;F. Kiessling
使药物安全有效地通过血脑屏障（BBB）仍然是一个挑战。在这期杂志的第36页，T. Lammers， P. Koczera， F. Kiessling和他们的同事展示了聚合物基微泡，在其外壳内含有氧化铁纳米颗粒，可以用来介导和监测血脑屏障的渗透。这样的治疗结构和概念被认为是有用的裁剪治疗中枢神经系统疾病。
Enabling safe and efficient drug delivery across the blood‐brain barrier (BBB) remains to be challenging. On page 36 of this issue, T. Lammers, P. Koczera, F. Kiessling, and colleagues show that polymer‐based microbubbles, containing iron oxide nanoparticles within their shell, can be employed to mediate and monitor BBB permeation. Such theranostic constructs and concepts are considered to be useful for tailoring the treatment of central nervous system disorders.