Detection and correction of merotelic kinetochore orientation by aurora B and its partners
Detection and correction of merotelic kinetochore orientation by aurora B and its partners
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DOI：
10.4161/cc.6.13.4452
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发表时间：
2007-07-01
期刊：
影响因子：
4.3
通讯作者：
Cimini, Daniela
中科院分区：
文献类型：
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作者：
Cimini, Daniela
细粒着丝点定向是一种着丝点与微管的错附，其中单个着丝点将微管与两个纺锤极而不是一个纺锤极结合。细粒附著在有丝分裂早期经常发生，如果在后期开始前不纠正，可以诱导后期滞后染色体和非整倍体。分裂着丝点的方向不会干扰中期板上的染色体排列，也不会激活有丝分裂纺锤体检查点。然而，染色体分裂附着的校正机制减少了进入后期的分裂着丝点的数量，从而防止了染色体的错误分离。许多不同的研究结果都支持Aurora B激酶通过磷酸化着丝点上的关键底物和促进着丝点微管的周转，在着丝点校正机制中起关键作用的观点。此外，最近的研究开始确定系统中可能的“传感器”，这些传感器能够检测到错误的附着并将其传达给极光b。在这里，我回顾了这些研究并讨论了一个如何在后期开始前检测和纠正分裂着丝点方向的模型。
Merotelic kinetochore orientation is a kinetochore- microtubule mis- attachment in which a single kinetochore binds microtubules to both spindle poles, rather than just one. Merotelic attachments occur frequently in early mitosis and can induce anaphase lagging chromosomes and aneuploidy if not corrected before anaphase onset. Merotelic kinetochore orientation does not interfere with chromosome alignment at the metaphase plate and does not activate the mitotic spindle checkpoint. However, a correction mechanism for merotelic attachment reduces the number of merotelic kinetochores entering anaphase, thus preventing chromosome mis- segregation. Results from many different studies support the idea that Aurora B kinase plays a critical role in this merotelic correction mechanism by phosphorylating key substrates at the kinetochore and promoting turnover of kinetochore microtubules. In addition, recent studies are starting to identify the possible ` sensors' of the system that would be able to detect the mis- attachment and communicate this to Aurora B. Here, I review these studies and discuss a model for how merotelic kinetochore orientation could be detected and corrected before anaphase onset.