Relaxin and its role in the development and treatment of fibrosis
Relaxin and its role in the development and treatment of fibrosis
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DOI：
10.1016/j.trsl.2009.03.007
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发表时间：
2009-07-01
影响因子：
7.8
通讯作者：
Bennett, Robert G.
中科院分区：
文献类型：
--
作者：
Bennett, Robert G.
松弛素是胰岛素超家族的肽类激素，参与促进细胞外基质重塑。这种性质是松弛素的许多众所周知的生殖功能的原因。最近的重要发现，包括松弛素受体的鉴定和松弛素缺失小鼠的开发，已经确定了松弛素作用的新靶点和机制，这导致了该领域前所未有的进展。松弛素已经成为许多组织中与年龄相关的纤维化的天然抑制剂，包括皮肤、肺、肾和心脏。此外，松弛素在预防和治疗各种实验诱导的纤维化模型中显示出功效。本文综述了松弛素研究的最新进展，重点介绍了非生殖器官纤维化的潜在转化研究领域。（翻译研究2009;154：1-6）
Relaxin, which is a peptide hormone of the insulin superfamily, is involved in the promotion of extracellular matrix remodeling. This property is responsible for many well-known reproductive functions of relaxin. Recent important findings, including the identification of the relaxin receptor and the development of the relaxin-null mouse, have identified new targets and mechanisms for relaxin's actions, which resulted in unprecedented advances in the field. Relaxin has emerged as a natural suppressor of age-related fibrosis in many tissues, which include the skin, lung, kidney, and heart. Furthermore, relaxin has shown efficacy in the prevention and treatment of a variety of models of experimentally induced fibrosis. The intention of this review is to present a summary of recent advances in relaxin research, with a focus on areas of potential translational research on fibrosis in nonreproductive organs. (Translational Research 2009;154:1-6)