Outcomes in HIV-infected patients admitted due to pandemic influenza
Outcomes in HIV-infected patients admitted due to pandemic influenza
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DOI：
10.1016/j.eimc.2012.02.007
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发表时间：
2012-12-01
影响因子：
2.5
通讯作者：
Lozano, Fernando
中科院分区：
文献类型：
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作者：
Lopez-Aldeguer, Jose;Iribarren, Jose A.;Lozano, Fernando
目的：目的：探讨影响HIV感染合并甲型H1N1流感住院患者的临床、流行病学和预后因素。方法：以确诊为流感感染的HIV感染患者为研究对象，采用多中心队列研究方法。我们分析了人口统计学数据、共病情况、严重事件（支气管肺炎、呼吸功能不全、呼吸窘迫、败血症、入住重症监护室、死亡）和结局。使用描述性统计量分析数据。使用卡方检验或Fisher精确检验（如适用）比较比例。使用Student t检验或Mann-Whitney检验比较定量变量。结果：共纳入22家医院的43例患者，其中男性占62.8%。平均年龄为43.3岁（四分位距[IQR]，38.4-48.4）。艾滋病毒被诊断的平均时间为14.5年（IQR，8.4-20.3）。CD 4淋巴细胞
Purpose: To determine the clinical, epidemiological and prognostic factors of HIV-infected patients with influenza A H1N1 admitted to hospital.Methods: The study population was HIV infected patients with confirmed influenza infection admitted to hospital in a multicenter cohort. We analyzed demographic data, comorbid conditions, severe events (bronchopneumonia, respiratory insufficiency, respiratory distress, sepsis, admission to intensive care unit, death) and outcome. Data were analyzed using descriptive statistics. Proportions were compared using the chi(2) test or Fisher exact test, when applicable. Quantitative variables were compared using the Student t test or Mann-Whitney test. Prognostic impact was analyzed using logistic regression.Results: A total of 43 patients, of whom 62.8% were male, were included from 22 hospitals. The mean age was 43.3 years (interquartile range [IQR], 38.4-48.4). HIV was diagnosed for a mean of 14.5 years (IQR, 8.4-20.3). CD4 lymphocyte was