Helicobacter pylori infection is associated with type 2 diabetes among a middle- and old-age Chinese population
Helicobacter pylori infection is associated with type 2 diabetes among a middle- and old-age Chinese population
复制标题
中国中老年人群幽门螺杆菌感染与2型糖尿病相关
DOI：
10.1002/dmrr.2677
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发表时间：
2016-01-01
影响因子：
8
通讯作者：
He, Meian
中科院分区：
文献类型：
--
作者：
Han, Xu;Li, Yaru;He, Meian
BackgroundAlthough the association of Helicobacter pylori (H.pylori) infection with diabetes mellitus has been evaluated, findings are controversial. This study investigated the association in a Chinese population.MethodsA cross-sectional study, including a total of 30810 subjects from the Dongfeng-Tongji Cohort study, was conducted. H.pylori status was measured via C-14 urea breath test. Association analysis was performed by logistic regression, with multivariable adjustment for sex, age, body mass index, smoking, alcohol consumption, family history of diabetes, physical activity and the use of antibiotics.ResultsAmong a middle-age and old-age Chinese population, individuals with H.pylori infection also had a higher prevalence of type 2 diabetes (21.3% versus 20.2%, p=0.026). H.pylori infection was associated with higher risk of type 2 diabetes [odds ratio, 1.08 (95% confidence interval: 1.02-1.14); p=0.008] after adjustment for other confounders. The association was significant among women, those who were above 65years old, not overweight or obese, and those who did not smoke, did not consume alcohol and without family history of diabetes. However, there was no interaction between H.pylori infection and other traditional risk factors on type 2 diabetes risk. Subjects with H.pylori infection had a lower level of high-density lipoprotein cholesterol (p
