Dietary Intake of Protein in Early Childhood Is Associated with Growth Trajectories between 1 and 9 Years of Age
Dietary Intake of Protein in Early Childhood Is Associated with Growth Trajectories between 1 and 9 Years of Age
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DOI：
10.3945/jn.116.237164
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发表时间：
2016-11-01
影响因子：
4.2
通讯作者：
Voortman, Trudy
中科院分区：
文献类型：
--
作者：
Braun, Kim V. E.;Erler, Nicole S.;Voortman, Trudy
背景：婴儿期高蛋白质摄入可能导致儿童期较高的体重指数（BMI）。然而，这些关联是否在不同蛋白质来源之间存在差异尚不清楚。目的：我们调查了儿童早期总蛋白质、不同来源蛋白质和单个氨基酸的摄入量之间的关联，并重复测量了9岁以下的身高、体重和BMI。这项研究在3564名参与R世代研究的儿童中进行，这是一项在荷兰鹿特丹进行的基于人群的前瞻性队列研究。通过食物频率问卷评估1年时总蛋白、动物蛋白、植物蛋白和单个氨基酸（包括蛋氨酸、精氨酸、赖氨酸、苏氨酸、缬氨酸、亮氨酸、异亮氨酸、苯丙氨酸、色氨酸、组氨酸、半胱氨酸、酪氨酸、丙氨酸、天冬酰胺、谷氨酰胺、甘氨酸、脯氨酸和丝氨酸）的摄入量。身高和体重分别在14、18、24、30、36和45个月以及6和9岁时测量，并计算BMI。结果：调整混杂因素后，线性混合模型显示，1岁时总蛋白质摄入量增加10 g/d与身高增加0.03 SD显著相关（95% CI：0.00，0.06），体重增加0.06-SD（95% CI：0.03，0.09），BMI增加0.05-SD（95% CI：0.03，0.08），直至9岁。协会更强的动物比植物蛋白质的摄入量，但没有不同的乳制品和非乳制品动物蛋白质或之间的特定amino acids.Conclusions：一个较高的蛋白质，特别是动物蛋白质的摄入量，在1年的年龄与更大的身高，体重，和BMI在儿童到9年的年龄。未来的研究应该探索生长激素的作用，并调查儿童早期的蛋白质摄入量是否会影响以后的健康。
Background: High protein intake in infancy might lead to a higher body mass index (BMI) in childhood. However, whether these associations differ between different sources of protein is unclear.Objective: We investigated associations between the intake of total protein, protein from different sources, and individual amino acids in early childhood and repeatedly measured height, weight, and BMI up to the age of 9 y.Methods: This study was performed in 3564 children participating in the Generation R Study, a population-based prospective cohort study in Rotterdam, Netherlands. Intakes of total protein, animal protein, vegetable protein, and individual amino acids (including methionine, arginine, lysine, threonine, valine, leucine, isoleucine, phenylalanine, tryptophan, histidine, cysteine, tyrosine, alanine, asparagine, glutamine, glycine, proline, and serine) at 1 y were assessed by using a food-frequency questionnaire. Height and weight were measured at the approximate ages of 14, 18, 24, 30, 36, and 45 mo and at 6 and 9 y, and BMI was calculated.Results: After adjustment for confounders, linear mixed models showed that a 10-g higher total protein intake/d at 1 y was significantly associated with a 0.03-SD greater height (95% Cl: 0.00, 0.06), a 0.06-SD higher weight (95% Cl: 0.03, 0.09), and a 0.05-SD higher BMI (95% Cl: 0.03, 0.08) up to the age of 9 y. Associations were stronger for animal than for vegetable protein intake but did not differ between dairy and nondairy animal protein or between specific amino acids.Conclusions: A higher intake of protein, especially animal protein, at 1 y of age was associated with a greater height, weight, and BMI in childhood up to 9 y of age. Future studies should explore the role of growth hormones and investigate whether protein intake in early childhood affects health later in life.