Effect of fruits, vegetables, or vitamin E-rich diet on vitamins E and C distribution in peripheral and brain tissues: Implications for brain function
Effect of fruits, vegetables, or vitamin E-rich diet on vitamins E and C distribution in peripheral and brain tissues: Implications for brain function
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DOI：
10.1093/gerona/55.3.b144
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发表时间：
2000-03-01
影响因子：
5.1
通讯作者：
Joseph, JA
中科院分区：
文献类型：
--
作者：
Martin, A;Prior, R;Joseph, JA
阿尔茨海默病相关的神经退行性疾病是衰老期间认知和运动功能下降的主要原因。有证据表明，含有大量抗氧化营养素的水果和蔬菜对神经功能很重要。我们研究了富含水果或蔬菜但维生素E低的饮食和维生素E高的饮食对Fischer 344大鼠模型大脑中维生素C和E分布以及多巴胺释放的影响，为期8个月。低维生素E饮食导致脑和外周组织中α-生育酚水平降低，而接受富含维生素E饮食的动物显示出显着增加，在500- 900%之间。补充维生素E组的血浆、心脏和肝脏中的维生素C浓度降低。它的结论是，补充或耗尽α-生育酚8个月的结果在脑组织和外周组织中的维生素E水平的显着变化，和不同的分布α-生育酚在整个不同的大脑区域检查。此外，与对照组相比，补充草莓、菠菜或维生素E的大鼠纹状体多巴胺释放显着增强。这些发现表明，除了众所周知的抗氧化剂外，水果和蔬菜中的其他营养物质可能对大脑功能很重要。
Age-related neurodegenerative conditions are the principal cause of declining cognitive and motor function during aging. Evidence support that fruits and vegetables containing generous amounts of antioxidant nutrients are important for neurological function. We investigated the effect of diets enriched with fruits or vegetables but low in vitamin E and a diet high in vitamin E on the distribution of vitamins C and E in the brain and dopamine release of Fischer 344 rat model, over an 8-month period. The low-vitamin E diet resulted in lowered alpha-tocopherol levels in brain and peripheral tissues, whereas the animals that received a diet enriched in vitamin E showed a significant increase, between 500-900%. Vitamin C concentration in plasma, heart, and liver was reduced in the vitamin E-supplemented group. It is concluded that supplementation or depletion of alpha-tocopherol for 8 months results in marked changes in vitamin E levels in brain tissue and peripheral tissues, and varied distribution of alpha-tocopherol throughout the different brain regions examined. In addition, compared to control group, rats supplemented with strawberry, spinach, or vitamin E showed a significant enhancement in striatal dopamine release. These findings suggest that other nutrients present in fruits and vegetables, in addition to the well-known antioxidants, may be important for brain function.