HYPERTONIC SALINE LOWERS RAISED INTRACRANIAL-PRESSURE IN CHILDREN AFTER HEAD TRAUMA
HYPERTONIC SALINE LOWERS RAISED INTRACRANIAL-PRESSURE IN CHILDREN AFTER HEAD TRAUMA
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DOI：
10.1097/00008506-199201000-00002
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发表时间：
1992-01-01
影响因子：
3.7
通讯作者：
PETERSON, B
中科院分区：
文献类型：
--
作者：
FISHER, B;THOMAS, D;PETERSON, B
18例颅内压升高的儿童创伤性脑损伤患者参加了一项双盲、交叉研究，比较了3%生理盐水和0.9%生理盐水输注对颅内压升高的影响。复苏后，每位患者分别给予不同浓度的生理盐水，监测ICP 2小时。0.9%生理盐水输注前的初始平均ICP为19.3 mm Hg，随后2小时试验期间的平均ICP为20.0 mm Hg （p = 0.32）。3%生理盐水注射前的基线平均ICP为19.9 mm Hg，注射后2小时的平均ICP为15.8 mm Hg （p = 0.003）。两组的中心静脉压没有明显变化，肾功能也没有变化。在所有18个试验中，3%生理盐水的血清钠浓度均升高。血清钠的最高浓度出现在3%生理盐水给药后30分钟。与生理盐水相比，3%生理盐水显著降低颅脑外伤后颅内压升高。通过中心静脉压测量的血管内脱水在研究期间未发生。
Eighteen pediatric patients who sustained traumatic brain injury were enrolled in a double-blind, crossover study comparing the effects of 3% saline and 0.9% saline infusions on raised intracranial pressure (ICP). After resuscitation, each patient received a bolus of each saline concentration, and ICP was monitored for 2 h. Initial mean ICP before 0.9% saline infusions equaled 19.3 mm Hg and averaged 20.0 mm Hg during the subsequent 2-h trials (p = 0.32). Baseline mean ICP before 3% saline administration equaled 19.9 mm Hg and averaged 15.8 mm Hg for 2 h postinfusion (p = 0.003). Central venous pressure did not change significantly in either group, nor did measurements of renal function. Serum sodium concentrations increased in all 18 trials of 3% saline. Maximal concentrations of serum sodium occurred 30 min after bolus administration of 3% saline. Three percent saline significantly reduces raised ICP after traumatic brain injury when compared with normal saline. Intravascular dehydration, as measured by central venous pressure, did not occur during the study period.