Oral administration of Lactobacillus strains isolated from breast milk as an alternative for the treatment of infectious mastitis during lactation
Oral administration of Lactobacillus strains isolated from breast milk as an alternative for the treatment of infectious mastitis during lactation
复制标题
DOI：
10.1128/aem.02599-07
复制
发表时间：
2008-08-01
影响因子：
4.4
通讯作者：
Rodriguez, J. M.
中科院分区：
文献类型：
--
作者：
Jimenez, E.;Fernandez, L.;Rodriguez, J. M.
在这项研究中，20名患有葡萄球菌性乳腺炎的妇女被随机分为两组。益生菌组每天摄入10 log（10）CFU的唾液乳杆菌CECT 5713和等量的加氏乳杆菌CECT 5714，持续4周，而对照组仅摄入赋形剂。这两种菌株最初都是从母乳中分离出来的。在第0天，益生菌组和对照组的平均葡萄球菌计数相似（分别为4.74和4.81 log（10）CFU/ml），但未检测到乳酸杆菌。在第30天，益生菌组的平均葡萄球菌计数（2.96 log（10）CFU/ml）低于对照组（4.79 log（10）CFU/ml）。L. salivarius CECT 5713和L. gasseri CECT 5714是从益生菌组10名女性中6名女性的牛奶样本中分离出来的。在第14天，在分配到益生菌组的妇女中没有观察到乳腺炎的临床体征，但在对照组妇女中，乳腺炎在整个研究期间持续存在。总之，L. salivarius CECT 5713和L. Gasseri CECT 5714似乎是治疗哺乳期感染性乳腺炎的有效替代物。
In this study, 20 women with staphylococcal mastitis were randomly divided in two groups. Those in the probiotic group daily ingested 10 log(10) CFU of Lactobacillus salivarius CECT5713 and the same quantity of Lactobacillus gasseri CECT5714 for 4 weeks, while those in the control one only ingested the excipient. Both lactobacillus strains were originally isolated from breast milk. On day 0, the mean staphylococcal counts in the probiotic and control groups were similar (4.74 and 4.81 log(10) CFU/ml, respectively), but lactobacilli could not be detected. On day 30, the mean staphylococcal count in the probiotic group (2.96 log(10) CFU/ml) was lower than that of the control group (4.79 log(10) CFU/ml). L. salivarius CECT5713 and L. gasseri CECT5714 were isolated from the milk samples of 6 of the 10 women of the probiotic group. At day 14, no clinical signs of mastitis were observed in the women assigned to the probiotic group, but mastitis persisted throughout the study period in the control group women. In conclusion, L. salivarius CECT5713 and L. gasseri CECT5714 appear to be an efficient alternative for the treatment of lactational infectious mastitis during lactation.