Distribution of the Escherichia coli Common Pilus among Diverse Strains of Human Enterotoxigenic E. coli
Distribution of the Escherichia coli Common Pilus among Diverse Strains of Human Enterotoxigenic E. coli
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DOI：
10.1128/jcm.00260-09
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发表时间：
2009-06-01
影响因子：
9.4
通讯作者：
Giron, Jorge A.
中科院分区：
文献类型：
--
作者：
Blackburn, Dana;Husband, Amanda;Giron, Jorge A.
大肠杆菌普通菌毛（Escherichiacoliccommonpilus，ECP）是由大肠埃希菌（Escherichiacoli）和致病性大肠杆菌（Escherichiacoli）共同产生的菌毛.大肠杆菌菌株。这种菌毛与肠致病性大肠杆菌的任何已知的定植因子（CF）无关。大肠杆菌（ETEC）。在这项研究中，我们调查了136个不同地理来源的人CF阳性和CF阴性ETEC菌株中ECP的分布和产生。主要菌毛亚基基因ecpA在这些菌株中的109株（80%）中发现，表明它广泛分布于ETEC菌株中。随机选择的43个菌株的一个子集的表型分析表明，58%的人产生ECP独立的CF的存在或不存在，一个百分比甚至高于最流行的CF。这些数据表明ECP在ETEC生物学中的重要作用，特别是在CF阴性菌株和人类感染中。
The Escherichia coli common pilus (ECP) is produced by commensal and pathogenic E. coli strains. This pilus is unrelated to any of the known colonization factors (CFs) of enterotoxigenic E. coli (ETEC). In this study, we investigated the distribution and production of ECP among a collection of 136 human CF-positive and CF-negative ETEC strains of different geographic origins. The major pilus subunit gene, ecpA, was found in 109 (80%) of these strains, suggesting that it is widely distributed among ETEC strains. Phenotypic analysis of a subset of 43 strains chosen randomly showed that 58% of them produced ECP independently of the presence or absence of CFs, a percentage even higher than that of the most prevalent CFs. These data suggest an important role for ECP in the biology of ETEC, particularly in CF-negative strains, and in human infection.