Nicotinic acetylcholine receptors on hippocampal neurons: Distribution on the neuronal surface and modulation of receptor activity
Nicotinic acetylcholine receptors on hippocampal neurons: Distribution on the neuronal surface and modulation of receptor activity
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DOI：
10.3109/10799899709036607
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发表时间：
1997-01-01
期刊：
影响因子：
--
通讯作者：
Maelicke, A
中科院分区：
文献类型：
--
作者：
Albuquerque, EX;Pereira, EFR;Maelicke, A
最近发展的一项技术，使用红外显微镜的可视化明确的区域上的神经元的表面上，和一个计算机化的显微操作系统，导致发现，功能性烟碱乙酰胆碱受体（nAChRs）的表达在树突上的密度比在大鼠海马神经元的索马。发现α-银环蛇毒素敏感的、携带α 7的nAChR和二氢-β-赤藓氨酸敏感的、α 4 β 2 nAChR的表达倾向于沿树突长度沿着增加，这表明这些受体可能高度参与海马神经元中突触功能的整合。本报告还讨论了这一发现，配体，如抗胆碱酯酶加兰他敏可以调节nAChR活性结合到一个新的受体网站，5-羟色胺（5-HT）可能作为一个内源性配体为这个网站。5-HT在体内调节nAChR功能的能力支持了这样的概念，即总体CNS功能不仅由神经元布线建立的神经元网络决定，而且由单一物质在一个系统中作为主要神经递质和在另一个系统中作为共递质的能力建立的化学网络决定。
The recent development of a technique that uses infrared microscopy for the visualization of well-defined areas on the surface of neurons, and a computerized system of micromanipulators led to the discovery that functional nicotinic acetylcholine receptors (nAChRs) are expressed at higher density on the dendrites than on the soma of rat hippocampal neurons. The finding that the expression of alpha-bungarotoxin-sensitive, alpha 7-bearing, nAChRs and dihydro-beta-erythroidine-sensitive,alpha 4 beta 2 nAChRs tends to increase along the dendritic length suggests that these receptors may be highly involved in the integration of synaptic functions in hippocampal neurons. The present report also discusses the finding that ligands such as the anticholinesterase galanthamine can modulate the nAChR activity by binding to a novel receptor site, and that 5-hydroxytryptamine (5-HT) may serve as an endogenous ligand for this site. The ability of 5-HT to modulate the nAChR function in vivo supports the concept that the overall CNS function is determined not only by the neuronal network established by the neuronal wiring, but also by a chemical network established by the ability of a single substance to act as the primary neurotransmitter in one system and as a co-transmitter in another system.