Myocardial Microvascular Dysfunction in Rheumatoid Arthritis Quantitation by 13N-Ammonia Positron Emission Tomography/Computed Tomography
Myocardial Microvascular Dysfunction in Rheumatoid Arthritis Quantitation by 13N-Ammonia Positron Emission Tomography/Computed Tomography
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DOI：
10.1161/circimaging.117.007495
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发表时间：
2019-01-01
影响因子：
7.5
通讯作者：
Bathon, Joan M.
中科院分区：
文献类型：
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作者：
Amigues, Isabelle;Russo, Cesare;Bathon, Joan M.
背景：本研究的目的是评估无临床心血管疾病的类风湿关节炎（RA）患者心肌微血管功能障碍的患病率及其与RA特征和心脏结构和功能测量的关系。方法：RA患者接受休息和血管扩张剂应激N-13氨正电子发射断层扫描和超声心动图检查。在静息和充血高峰时定量测定心肌总血流量。心肌血流储备（MFR）计算为峰值应激心肌血流量/静息心肌血流量。少数无症状和有症状的非ra对照也进行了评估。结果：在RA患者中，平均+/- SD MFR为2.9 +/- 0.8，其中29%的MFR降低(
BACKGROUND: The goal of this study was to assess the prevalence of myocardial microvascular dysfunction in rheumatoid arthritis (RA) patients without clinical cardiovascular disease and its association with RA characteristics and measures of cardiac structure and function.METHODS: Participants with RA underwent rest and vasodilator stress N-13 ammonia positron emission tomography and echocardiography. Global myocardial blood flow was quantified at rest and during peak hyperemia. Myocardial flow reserve (MFR) was calculated as peak stress myocardial blood flow/rest myocardial blood flow. A small number of asymptomatic and symptomatic non-RA controls were also evaluated.RESULTS: In RA patients, mean +/- SD MFR was 2.9 +/- 0.8, with 29% having reduced MFR (