Swallowing difficulty in Parkinson's disease
Swallowing difficulty in Parkinson's disease
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DOI：
10.1016/s0303-8467(97)00606-9
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发表时间：
1997-05-01
影响因子：
1.9
通讯作者：
Liu, HC
中科院分区：
文献类型：
--
作者：
Fuh, JL;Lee, RC;Liu, HC
吞咽困难是帕金森病（PD）的常见和潜在的严重并发症。我们检查了19例PD患者（15名男性和4名女性，平均年龄68.42岁，平均Hoehn和Yahr分期1.8）的口咽吞咽能力，在口服左旋多巴（联合苄丝肼）之前和之后使用改良钡吞咽。12例（63.2%）患者表现出吞咽异常的客观证据;尽管只有6例患者（31.6%）有主观主诉。最常见的异常是壶腹窦和梨状窦残留（47.4%和42.1%），其次是吞咽反射延迟（26.3%）。3例患者表现为无症状性误吸。在12例吞咽异常的患者中，6例（50%）在左旋多巴治疗后表现出客观改善，而其余6例无变化。在前一组的6名患者中，1名患者在口腔期表现出改善，但在咽期表现出恶化。我们得出结论，PD患者有很高比例的客观吞咽异常，可以通过左旋多巴治疗减少一半的患者。(C)1997年Elsevier Science B.V.
Dysphagia is a frequent and potentially serious complication of Parkinson's disease (PD). We examined the oropharyngeal swallowing ability in 19 PD patients (15 men and 4 women, mean age 68.42 years, mean Hoehn and Yahr stage 1.8) using modified barium swallow before and after administering oral levodopa (in combination with benserazide). Twelve (63.2%) patients demonstrated objective evidence of swallowing abnormalities; although only six patients (31.6%) had subjective complaints. Vallecula sinus and pyriform sinus residues were the most frequent abnormalities (47.4% and 42.1%); followed by delayed swallowing reflex (26.3%). Three patients demonstrated silent aspiration. In the 12 patients with abnormal swallowing, six (50%) showed objective improvement after levodopa treatment, while the remaining six showed no change. Of the former group of six, one patient showed improvement in the oral phase, but deterioration in the pharyngeal phase. We concluded that PD patients had a high percentage of objective swallowing abnormalities which could be reduced in half of the patients through the administration of levodopa treatment. (C) 1997 Elsevier Science B.V.