Higher antibody, but not cell-mediated, responses to vaccination in high physically fit elderly
Higher antibody, but not cell-mediated, responses to vaccination in high physically fit elderly
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DOI：
10.1152/japplphysiol.00790.2006
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发表时间：
2007-03-01
影响因子：
3.3
通讯作者：
Woods, Jeffrey A.
中科院分区：
文献类型：
--
作者：
Keylock, K. Todd;Lowder, Thomas;Woods, Jeffrey A.
本研究的目的是检查心血管健康是否独立于混杂因素，与老年人（60 - 76岁）对临床相关挑战的免疫反应有关。13名久坐、低健身(LF；最大O-2摄取= 21.1 +/- 1.1 ml(.)kg(-1) （.) min(-1)）和13名体力活动、高健身(HF；最大O-2摄取= 46.8 +/- 3.4 ml(.)kg（-1)min(-1)）的老年人参加了这项研究。对饮食摄入量进行了评估，并进行了一系列心理社会测试。对流感（Fluzone）和破伤风类毒素（TT）疫苗接种和延迟型超敏性皮肤试验进行体内抗体和体外增殖和细胞因子反应。通过血凝抑制测量，HF老年人对流感疫苗中包含的三种毒株中的两种表现出更高的抗体反应，但在流感特异性体外增殖或ifn - γ或IL-10的产生方面，两组之间没有差异。HF老年人对TT疫苗表现出较低的IgG(1)应答和较高的IgG(2)应答的趋势。然而，tt特异性体外增殖或ifn - γ或IL-10的产生没有差异。相反，HF受试者对植物血凝素有更高的增殖反应。此外，对真菌抗原的延迟型超敏反应在两组之间没有差异。这些结果表明，在考虑了混杂因素后，HF老年人对流感疫苗的抗体反应更高，对TT的抗体反应有Th2偏倚。几乎没有证据表明HF对Fluzone或TT疫苗（在外周血中测量）或对体内其他召回抗原有更好的细胞介导免疫反应。
The purpose of this study was to examine whether cardiovascular fitness, independent of confounding factors, was associated with immune responsiveness to clinically relevant challenges in older adults (60 - 76 yr). Thirteen sedentary, low-fit (LF; maximal O-2 uptake = 21.1 +/- 1.1 ml (.) kg(-1) (.) min(-1)) and 13 physically active, high-fit (HF; maximal O-2 uptake = 46.8 +/- 3.4 ml(.)kg(-1.)min(-1)) older adults participated in this study. Dietary intake was assessed, and a battery of psychosocial tests was administered. In vivo antibody and ex vivo proliferative and cytokine responses to influenza (Fluzone) and tetanus toxoid ( TT) vaccination and delayed-type hypersensitivity skin tests were performed. HF elderly individuals displayed a higher antibody response to two of the three strains included in the Fluzone vaccine as measured by hemagluttination inhibition, but there was no difference between groups in influenza-specific ex vivo proliferation or IFN-gamma or IL-10 production. HF elderly individuals exhibited a lower IgG(1) response and a tendency for a higher IgG(2) response to the TT vaccine. There were, however, no differences in TT-specific ex vivo proliferation or IFN-gamma or IL-10 production. In contrast, HF subjects had higher proliferative responses to phytohemagluttinin. In addition, there were no differences in delayed-type hypersensitivity responses to fungal antigens between groups. These results suggest that, after accounting for confounding factors, HF elderly individuals have higher antibody responses to Fluzone vaccine and a Th2 skewing of the antibody response to TT. There was little evidence that HF mounted better cell-mediated immune responses to the Fluzone or TT vaccine measured in peripheral blood cells or to other recall antigens in vivo.