From cell senescence to age-related diseases: differential mechanisms of action of senescence-associated secretory phenotypes.
From cell senescence to age-related diseases: differential mechanisms of action of senescence-associated secretory phenotypes.
复制标题
DOI：
10.5483/bmbrep.2015.48.10.122
复制
发表时间：
2015-10
期刊：
影响因子：
3.8
通讯作者：
Yoon G
中科院分区：
文献类型：
--
作者：
Byun HO;Lee YK;Kim JM;Yoon G
细胞衰老是细胞进入一种永久性细胞周期停滞状态的过程。它通常被认为是机体老化和年龄相关疾病的基础。然而，细胞衰老导致衰老和年龄相关病理的机制尚不清楚。近年来的研究表明，衰老细胞对组织微环境产生不利影响，产生病理促进因子或加重因子。衰老细胞导致的最显著的环境效应是衰老相关分泌表型（SASP），它由多种促炎细胞因子的表达和分泌显著增加组成。仔细研究sasp的成分及其作用机制，可以提高我们对年龄相关疾病病理背景的理解。在这篇综述中，我们主要关注SASP相关基因的差异表达，以及SASP成分在衰老过程中的差异表达。我们还提供了SASP成分的可能作用机制的观点，以及表达SASP的衰老细胞对年龄相关病理的潜在贡献。[BMB报告2015；48 (10): 549 - 558)
Cellular senescence is a process by which cells enter a state of permanent cell cycle arrest. It is commonly believed to underlie organismal aging and age-associated diseases. However, the mechanism by which cellular senescence contributes to aging and age-associated pathologies remains unclear. Recent studies showed that senescent cells exert detrimental effects on the tissue microenvironment, generating pathological facilitators or aggravators. The most significant environmental effector resulting from senescent cells is the senescence-associated secretory phenotype (SASP), which is constituted by a strikingly increased expression and secretion of diverse pro-inflammatory cytokines. Careful investigation into the components of SASPs and their mechanism of action, may improve our understanding of the pathological backgrounds of age-associated diseases. In this review, we focus on the differential expression of SASP-related genes, in addition to SASP components, during the progress of senescence. We also provide a perspective on the possible action mechanisms of SASP components, and potential contributions of SASP-expressing senescent cells, to age-associated pathologies. [BMB Reports 2015; 48(10): 549-558]