Expression of syndecan-1 in human placenta and decidua
Expression of syndecan-1 in human placenta and decidua
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DOI：
10.1016/s0143-4004(98)90004-2
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发表时间：
1998-03-01
期刊：
影响因子：
3.8
通讯作者：
Anttila, L
中科院分区：
文献类型：
--
作者：
Jokimaa, V;Inki, P;Anttila, L
Syndecan-1是一种细胞表面硫酸肝素蛋白多糖，可与细胞外基质（ECM）、生长因子和抗凝血酶III结合。syndecan-1在小鼠胚胎发育过程中的早期表达提示其在胚胎与蜕膜ECM之间的通讯中可能起作用。本研究利用免疫组织化学方法发现，syndecan-1在滋养细胞中的表达随滋养细胞分化而变化。绒毛膜绒毛中的合胞滋养细胞表现出syndecan-1的顶端表达。这表明这种表达仅限于非迁移、非增殖的滋养细胞。人胎盘滋养细胞表达syndecan-1的方式与胎龄无关。这种表达在流产中不会改变。在子痫前期，绒毛合体滋养细胞上syndecan-1的染色较正常妊娠弱，但在胎盘床上表达相似。syndecan-1在绒毛膜绒毛中独特的顶端定位，在其他组织中未被发现，表明其可能通过生长因子结合和绒毛间循环抗凝在母婴通信中发挥潜在作用。(c) 1998年；桑德斯有限公司
Syndecan-1 is a cell surface heparan sulphate proteoglycan, which binds to the extracellular matrix (ECM), growth factors and antithrombin III. The early expression of syndecan-1 during mouse embryonic development suggests a potential role in the communication between the embryo and the ECM of decidua. Using immunohistochemical methods, the present study showed that the expression of syndecan-1 in the trophoblast cells changes along trophoblast differentation. The syncytiotrophoblasts in the chorionic villi exhibited an apical expression of syndecan-1. This suggests that the expression is restricted to non-migrating, non-proliferating trophoblasts. The mode of syndecan-1 expression by human placental trophoblasts is independent of gestational age. The expression is not changed in miscarriages. In pre-eclampsia, the staining for syndecan-1 on the villous syncytiotrophoblast is weaker compared to normal pregnancy, but in placental bed the expression is similar. The unique apical localization of syndecan-1 in chorionic villi, not detected in any other tissues, suggests a potential role in fetomaternal communication probably via growth factor binding and in anticoagulation of intervillous circulation. (C) 1998 W. B. Saunders Company Ltd.