MICROSTIMULATION OF THE PRIMATE NEOSTRIATUM .2. SOMATOTOPIC ORGANIZATION OF STRIATAL MICROEXCITABLE ZONES AND THEIR RELATION TO NEURONAL RESPONSE PROPERTIES
MICROSTIMULATION OF THE PRIMATE NEOSTRIATUM .2. SOMATOTOPIC ORGANIZATION OF STRIATAL MICROEXCITABLE ZONES AND THEIR RELATION TO NEURONAL RESPONSE PROPERTIES
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DOI：
10.1152/jn.1985.53.6.1417
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发表时间：
1985-01-01
影响因子：
2.5
通讯作者：
DELONG, MR
中科院分区：
文献类型：
--
作者：
ALEXANDER, GE;DELONG, MR
新纹状体神经元的感觉运动反应特性的特点与未麻醉恒河猴纹状体内微刺激的运动效应的评估。神经元活性和微兴奋性以250至500微米的间隔进行评估，在某些情况下，以25至100微米的间隔进行评估。结果是基于878壳核和224尾状核神经元的功能表征和微刺激在每个这些记录站点的影响分析。记录/刺激位点位于立体定位平面A6和A22之间的81个微电极轨迹从三只猴子。共443（50.4%）壳核神经元表现出离散的感觉运动检查的反应。感觉运动反应的神经元，232（52.4%）表现出增加的放电率与主动和被动运动的特定身体部位。另外193个（43.6%）细胞仅在猴子特定身体部位的主动运动期间增加放电率。其余18个（4.0%）细胞似乎只对被动体感刺激作出反应。壳核神经元的感觉运动反应区的大小从整个肢体到单个关节不等。壳核神经元在整个核的吻尾侧范围内组织。涉及腿的感觉运动反应区的神经元位于背外侧壳核，口面代表位于ventromedially，和那些手臂代表位于中间位置。微刺激诱发个别身体部位的离散运动在21.6%的878壳核网站。超过95%（181/190）的有效部位位于壳核吻尾侧范围的中半部分，在立体定位平面A10和A17之间。微刺激揭示的躯体组织的模式是相同的，来自壳核神经元的感觉运动反应特性。此外，观察到从给定SMZ诱发的运动与局部神经元的功能特性之间的密切对应关系。在壳核中获得的结果相反，在尾状核中的224个刺激位点是微兴奋的，只有17（7.6%）的尾状核神经元具有可定义的感觉运动反应特性。这与以下观点一致：灵长类动物的壳核由于其与感觉运动和运动前皮质区的解剖学联系，更直接地参与运动功能，而尾状核由于其与皮质“关联”区的联系，参与更复杂的行为功能。
Sensorimotor response properties of neostriatal neurons were characterized in conjunction with assessments of the motor effects of intrastriatal microstimulation in unanesthetized rhesus monkeys. Neuronal activity and microexcitability were assessed at 250- to 500-micron intervals and, in some cases, at 25- to 100-micron intervals. The results are based on the functional characterization of 878 putamen and 224 caudate neurons and analysis of the effects of microstimulation at each of these recording sites. Recording/stimulation sites were located between stereotaxic planes A6 and A22 in 81 microelectrode tracks from three monkeys. A total of 443 (50.4%) putamen neurons showed discrete responses to the sensorimotor examination. Of neurons with sensorimotor responses, 232 (52.4%) showed increased rates of discharge in relation to both active and passive movements of specific body parts. An additional 193 (43.6%) cells increased their rates of discharge only during the monkey's active movements of specific body parts. The remaining 18 (4.0%) cells appeared to respond exclusively to passive somatosensory stimulation. The sensorimotor response areas of putamen neurons ranged in size from an entire limb to a single joint. Putamen neurons were somatotopically organized throughout the rostrocaudal extent of the nucleus. Neurons with sensorimotor response areas involving the leg were located in the dorsolateral putamen, those with orofacial representations were located ventromedially, and those with arm representations were located in an intermediate position. Microstimulation evoked discrete movements of individual body parts at 21.6% of the 878 putamen sites. Over 95% (181/190) of the effective sites were located within the central half of the rostrocaudal extent of the putamen, between stereotaxic planes A10 and A17. The pattern of somatotopic organization revealed by microstimulation was the same as that derived from sensorimotor response properties of putamen neurons. Moreover, a close correspondence was observed between the movements evoked from a given SMZ and the functional properties of local neurons. In contrast to the results obtained in the putamen, none of the 224 stimulation sites in the caudate nucleus was microexcitable, and only 17 (7.6%) of the caudate neurons had definable sensorimotor response properties. This is consistent with the view that the primate putamen, by virtue of its anatomic connections with the sensorimotor and premotor cortical fields, is more directly involved in motor functions, whereas the caudate nucleus, by virtue of its connections with cortical ”association“ areas, is involved in more complex behavioral functions.