Characterization of β-cell function impairment in first-degree relatives of type 2 diabetic subjects:: modeling analysis of 24-h triple-meal tests
Characterization of β-cell function impairment in first-degree relatives of type 2 diabetic subjects:: modeling analysis of 24-h triple-meal tests
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DOI：
10.1152/ajpendo.00175.2004
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发表时间：
2005-03-01
影响因子：
5.1
通讯作者：
Ferrannini, E
中科院分区：
文献类型：
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作者：
Mari, A;Gastaldelli, A;Ferrannini, E
To investigate early secretory defects in prediabetes, we evaluated beta-Cell function and insulin sensitivity (M value, by euglycemic clamp) in 26 normotolerant first-degree relatives of type 2 diabetic patients (FDR) and 17 age- and weight-matched control subjects. beta-Cell function was assessed by modeling analysis of glucose and C-peptide concentrations measured during 24 h of standardized living conditions. Fasting and total insulin secretion (ISR) were increased in FDR, as was ISR at a reference 5 mM glucose level (ISR5, 107+/-6 vs. 87+/-6 pmol.min(-1).m(-2), P
