Evaluation of serum selenium levels in Turkish women with gestational diabetes mellitus, glucose intolerants, and normal controls
Evaluation of serum selenium levels in Turkish women with gestational diabetes mellitus, glucose intolerants, and normal controls
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DOI：
10.1007/s12011-007-8087-2
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发表时间：
2008-06-01
影响因子：
3.9
通讯作者：
Coskun, Ayhan
中科院分区：
文献类型：
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作者：
Kilinc, Metin;Guven, Melih A.;Coskun, Ayhan
本研究旨在探讨妊娠期糖尿病（GDM）患者和糖耐量异常者血清硒水平之间的关系，并与糖耐量正常孕妇进行比较。这项横断面研究前瞻性地对178名在妊娠24 - 28周之间接受50 g口服葡萄糖耐量试验的孕妇进行，这些孕妇根据其葡萄糖耐量状态与妊娠期糖尿病进行分组（A组，异常1-和3-h葡萄糖耐量试验; n = 30），葡萄糖不耐B组：1小时葡萄糖耐量试验异常，3小时葡萄糖耐量试验正常，n = 47; C组：1小时葡萄糖耐量试验正常，n = 101。血清硒水平用石墨炉原子吸收分光光度计使用基体改进剂。A组（胎龄= 24.8 [24 - 27]）、B组（胎龄= 24.7 [24 - 27]）和C组（胎龄= 25 [24 - 28]）诊断时的中位母亲年龄和胎龄无差异。妊娠期糖尿病患者和糖耐量异常者血清硒水平明显低于正常孕妇（P <0.001）。硒与血糖水平呈显著负相关，补充硒对GDM患者有益，可预防或延缓糖尿病继发并发症的发生。
The aim of the study was to investigate the association between serum selenium levels in patients with gestational diabetes mellitus (GDM) and glucose intolerants and compare them with those of glucose-tolerant pregnant women. This cross-sectional study was prospectively performed in a total of 178 pregnant women undergoing a 50-g oral glucose tolerance test between 24 and 28 weeks of gestation who were grouped according to their status of glucose tolerance as with gestational diabetes (group A, abnormal 1- and 3-h glucose tolerance test; n=30), glucose intolerant (group B, abnormal 1-h but normal 3-h glucose tolerance test; n=47), or normal controls (group C, normal 1-h glucose test; n=101). Serum selenium levels were measured with a graphite furnace atomic absorption spectrophotometer using a matrix modifier. Median maternal age and gestational age at the time of diagnosis in group A (gestational age=24.8 [24-27]), group B (gestational age=24.7 [24-27]), and group C (gestational age=25 [24-28]) did not differ. Patients with gestational diabetes mellitus and those with glucose intolerants had lower selenium level than that of the normal pregnant women (P < 0.001). There was a significant inverse correlation between selenium and blood glucose level, and also selenium supplementation might prove beneficial on patients with GDM and prevent or retard them from secondary complications of diabetes.