Cultural Consonance, a 5HT2A Receptor Polymorphism, and Depressive Symptoms: A Longitudinal Study of Gene x Culture Interaction in Urban Brazil
Cultural Consonance, a 5HT2A Receptor Polymorphism, and Depressive Symptoms: A Longitudinal Study of Gene x Culture Interaction in Urban Brazil
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DOI：
10.1002/ajhb.20823
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发表时间：
2009-01-01
影响因子：
2.9
通讯作者：
Dos Santos, Jose Ernesto
中科院分区：
文献类型：
--
作者：
Dressler, William W.;Balieiro, Mauro C.;Dos Santos, Jose Ernesto
在巴西城市的这项研究中，我们研究，作为抑郁症状的预测因子，在2A受体的单核苷酸多态性在5-羟色胺系统（-1438G/A）和家庭生活中的文化和谐之间的相互作用，在何种程度上个人认为她的家庭对应于一个广泛共享的文化模式的原型家庭的措施。社区样本的144名成年人进行了为期2年的跟踪调查。通过将个人对自己家庭的看法与文化共识分析得出的家庭共同文化模式联系起来，评估家庭生活中的文化和谐。使用从白细胞提取的DNA的标准方案对2A血清素受体中的-1438G/A多态性进行基因分型。协变量包括年龄、性别、社会经济地位和压力性生活事件。家庭生活中的文化和谐与抑郁症状有前瞻性相关。此外，基因型与家庭生活中的文化一致性之间存在显著的交互作用。对于具有2A受体基因-1438G/A多态性的A/A变体的个体，家庭生活中的文化和谐对抑郁症状的影响在2年内更大（β =-0.533，P < 0.01），而G/A（β =-0.280，P < 0.10）或G/G（β =-0.272，P < 0.05）变异个体的效应更大。这些结果与基因型调节有文化意义的社会经验对抑郁症状的影响的过程是一致的。Am. J.哈姆。21：91-97，2009. (C)2008 Wiley-Liss，Inc.
In this study in urban Brazil we examine, as a predictor of depressive symptoms, the interaction between a single nucleotide polymorphism in the 2A receptor in the serotonin system (-1438G/A) and cultural consonance in family life, a measure of the degree to which an individual perceives her family as corresponding to a widely shared cultural model of the prototypical family. A community sample of 144 adults was followed over a 2-year-period. Cultural consonance in family life was assessed by linking individuals' perceptions of their own families with a shared cultural model of the family derived from cultural consensus analysis. The -1438G/A polymorphism in the 2A serotonin receptor was genotyped using a standard protocol for DNA extracted from leukocytes. Covariates included age, sex, socioeconomic status, and stressful life events. Cultural consonance in family life was prospectively associated with depressive symptoms. In addition, the interaction between genotype and cultural consonance in family life was significant. For individuals with the A/A variant of the -1438G/A polymorphism of the 2A receptor gene, the effect of cultural consonance in family life on depressive symptoms over a 2-year-period was larger (beta = -0.533, P < 0.01) than those effects for individuals with either the G/A (beta = -0.280, P < 0.10) or G/G (beta = -0.272, P < 0.05) variants. These results are consistent with a process in which genotype moderates the effects of culturally meaningful social experience on depressive symptoms. Am. J. Hum. Biol. 21:91-97, 2009. (C) 2008 Wiley-Liss, Inc.