Postmenopausal levels of endogenous sex hormones and risk of colorectal cancer.
Postmenopausal levels of endogenous sex hormones and risk of colorectal cancer.
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绝经后内源性激素水平和结直肠癌的风险。
DOI：
10.1158/1055-9965.epi-08-0777
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发表时间：
2009-01
期刊：
影响因子：
--
通讯作者：
Zeleniuch-Jacquotte A
中科院分区：
文献类型：
--
作者：
Clendenen TV;Koenig KL;Shore RE;Levitz M;Arslan AA;Zeleniuch-Jacquotte A
观察性流行病学研究和随机试验报告了口服激素替代疗法对结直肠癌风险的保护作用。只有一个以前的前瞻性研究，妇女健康倡议观察性研究，报告了内源性激素和结肠直肠癌之间的关系。与预期相反，研究人员发现，循环雌二醇水平较高的女性患结直肠癌的风险增加。我们在纽约大学妇女健康研究前瞻性队列中进行了一项病例对照研究，以评估内源性雌酮、雌二醇和性激素结合球蛋白（SHBG）水平与结直肠癌风险之间的关系。我们测量了148名随后患结直肠癌的妇女和293名匹配的对照者的血清样本中的激素和SHBG。循环雌酮水平与结直肠癌风险呈正相关：雌酮最高与最低四分位数的比值比为1.8（95%置信区间= 1.0-3.3）。我们发现SHBG和结直肠癌之间的负相关性不显著，在调整体重指数后消失。我们没有发现雌二醇和结直肠癌风险之间的关联，但我们不能排除潜在的关联，因为测量中存在大量的实验室误差。我们的研究结果表明，内源性雌酮可能与绝经后妇女结直肠癌的风险增加。
Observational epidemiologic studies and randomized trials have reported a protective effect of oral hormonal replacement therapy on risk of colorectal cancer. Only one previous prospective study, the Women’s Health Initiative Observational Study, has reported on the relationship between endogenous hormones and incident colorectal cancer. Contrary to expectation, the investigators found that women with higher circulating estradiol levels were at increased risk of developing colorectal cancer. We conducted a case-control study nested within the New York University Women’s Health Study prospective cohort to evaluate the association between endogenous levels of estrone, estradiol, and sex hormone binding globulin (SHBG) with risk of colorectal cancer. We measured hormones and SHBG in serum samples collected at enrollment from a total of 148 women who subsequently developed colorectal cancer and 293 matched controls. Circulating estrone levels were positively associated with risk of colorectal cancer: the odds ratio for the highest versus lowest quartile of estrone was 1.8 (95% confidence interval = 1.0–3.3). We found a non-significant inverse association between SHBG and colorectal cancer, which disappeared after adjusting for body mass index. We did not find an association between estradiol and colorectal cancer risk, but we cannot rule out a potential association because of substantial laboratory error in the measurement. Our results suggest that endogenous estrone may be associated with increased risk of colorectal cancer in postmenopausal women.