Cardiac Models in Drug Discovery and Development: A Review
Cardiac Models in Drug Discovery and Development: A Review
复制标题
DOI：
10.1615/critrevbiomedeng.v39.i5.30
复制
发表时间：
2011-01-01
影响因子：
--
通讯作者：
Saucerman, Jeffrey J.
中科院分区：
文献类型：
--
作者：
Amanfu, Robert K.;Saucerman, Jeffrey J.
心血管疾病是发达国家的主要死因之一。为心力衰竭等疾病开发新疗法至关重要，但这受到药物开发中高损耗率的阻碍。在最后一关批准时撤回药物主要是因为它们对正常心律的不可预测的影响。近50年来，心脏计算模型的出现极大地帮助了人们对心脏功能的理解。最近，这些模型越来越多地被应用于设计和理解心脏病的治疗方法。本文将讨论如何电生理，细胞信号和代谢的细胞模型已被用于研究心脏疾病，包括心律失常，缺血和心力衰竭的药物治疗。
Cardiovascular diseases are among the leading causes of death in the developed world. Developing novel therapies for diseases like heart failure is crucial, but this is hampered by the high attrition rate in drug development. The withdrawal of drugs at the final hurdle of approval is mostly because of their unpredictable effects on normal cardiac rhythm. The advent of cardiac computational modeling in the last 5 decades has aided the understanding of heart function significantly. Recently, these models increasingly have been applied toward designing and understanding therapies for cardiac disease. This article will discuss how cellular models of electrophysiology, cell signaling, and metabolism have been used to investigate pharmacologic therapies for cardiac diseases including arrhythmia, ischemia, and heart failure.