CEREBRAL OXYGENATION AND METABOLISM DURING PROGRESSIVE HYPERTHERMIA
CEREBRAL OXYGENATION AND METABOLISM DURING PROGRESSIVE HYPERTHERMIA
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DOI：
10.1152/ajplegacy.1970.219.6.1784
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发表时间：
1970-01-01
影响因子：
--
通讯作者：
FRANKEL, HM
中科院分区：
文献类型：
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作者：
NEMOTO, EM;FRANKEL, HM
方法用戊巴比妥钠(30 mg/kg)麻醉雄性和雌性犬(体重13.2-25.5 kg)。将插管放置在气管、右股静脉和动脉、右肱动脉以及上矢状窦中。使用插入直肠约 10-15 cm 的热敏电阻监测直肠温度（T&）。通过使用连续输注同位素和外部闪烁的 4-碘安替比林-I I31 技术测定脑血流量 (43)。适用于狗的技术已在其他地方描述过 (37)。对颅骨背部和侧面的颞部和相关肌肉组织进行大规模切除，以进行放射性扫描头骨的。
METHODSMale and female dogs (body wt 13.2-25.5 kg) were anesthetized with sodium pentobarbital(30 mg/kg). Cannulas were placed in the trachea, right femoral vein and artery, right brachial artery, and in the superior sagittal sinus. Rectal temperature(T& was monitored with a thermistor inserted approximately 10-15 cm into the rectum.Cerebral blood flow was determined by a 4-iodoantipyrine-I I31 technique using continuous infusion of isotope and external scintillation(43). The technique adapted for dog has been described elsewhere (37). Massive resection of temporal and associated musculature on the dorsal and lateral aspects of the skull was carried out to permit radioactive scanning of the skull.