Regulation of glucocorticoid receptor immunoreactivity in the rat hippocampus by androgenic-anabolic steroids.
Regulation of glucocorticoid receptor immunoreactivity in the rat hippocampus by androgenic-anabolic steroids.
复制标题
雄激素合成代谢类固醇对大鼠海马糖皮质激素受体免疫反应性的调节。
DOI：
10.1016/0006-8993(92)91226-5
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发表时间：
1992
期刊：
影响因子：
2.9
通讯作者：
Harlan,RE
中科院分区：
文献类型：
--
作者：
Ahima,RS;Harlan,RE
为了确定雄激素合成代谢类固醇（AAS）是否调节糖皮质激素受体（GR），本研究在去肾上腺雄性大鼠海马中检测了三种常用的雄激素合成代谢类固醇（睾酮、癸酸诺龙和十一烯酸胆甾酮）对GR免疫反应性（ir）的影响。AAS处理1周后，CA1锥体细胞和齿状回颗粒细胞的核grr升高。这些发现提示GR在雄激素合成代谢类固醇介导中枢神经系统的一些作用。
To determine whether androenic-anabolic steroids (AAS) regulate glucocorticoid receptors (GR), the effects of a mixture of three commonly abused AAS (testosterone cypionate, nandrolone decanoate and boldenone undecylenate) on GR immunoreactivity (ir), were examined in hippocampi of adrenalectomized male rats. Treatment with AAS for 1 week increased nuclear GRir in pyramidal cells of CA1, and granule cells of the dentate gyrus. These findings suggest a role for GR in the mediation of some of the CNS effects of androgenic-anabolic steroids.