Physiological role of metastin/kisspeptin in regulating gonadotropin-releasing hormone (GnRH) secretion in female rats
Physiological role of metastin/kisspeptin in regulating gonadotropin-releasing hormone (GnRH) secretion in female rats
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DOI：
10.1016/j.peptides.2008.08.004
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发表时间：
2009-01-01
期刊：
影响因子：
3
通讯作者：
Tsukamura, Hiroko
中科院分区：
文献类型：
--
作者：
Ohkura, Satoshi;Uenoyama, Yoshihisa;Tsukamura, Hiroko
各种研究试图揭示转移酶/kisspeptin在控制促性腺激素释放激素（GnRH）释放中的生理作用。大量证据表明，前腹侧心室周围核（AVPV）中的转移素/kisspeptin神经元群参与了GnRH激增的产生，从而诱导了啮齿类动物的排卵，从而成为雌激素正反馈的目标。雌性在AVPV中有明显的转移蛋白/kisspeptin神经元群，而雄性在细胞核中只有少数细胞体，这表明雄性在AVPV中没有产生涌动机制或正反馈作用是由于AVPV中转移蛋白/kisspeptin神经元群有限。另一方面，弓形核（ARC）转移蛋白/kisspeptin神经元群被认为参与强直GnRH释放的调节。ARC转移蛋白/kisspeptin神经元的表达无性别差异，两性均受性腺激素抑制。因此，转移素/kisspeptin神经元的ARC群是雌激素对补性GnRH释放的负反馈作用的靶点。哺乳期大鼠模型进一步证明，etastin/kisspeptin神经元中的ARC参与GnRH脉冲的产生，因为哺乳期大鼠的脉动性促黄体生成素（LH）释放被哺乳刺激深度抑制，LH脉冲抑制与ARC metastin/kisspeptin和KISS-1基因表达的抑制密切相关。(C) 2008爱思唯尔公司版权所有。
Various studies have attempted to unravel the physiological role of metastin/kisspeptin in the control of gonadotropin-releasing hormone (GnRH) release. A number of evidences suggested that the population of metastin/kisspeptin neurons in the anteroventral periventricular nucleus (AVPV) is involved in generating a GnRH surge to induce ovulation in rodents, and thus the target of estrogen positive feedback. Females have an obvious metastin/kisspeptin neuronal population in the AVPV, but males have only a few cell bodies in the nucleus, suggesting that the absence of the surge-generating mechanism or positive feedback action in males is due to the limited AVPV metastin/kisspeptin neuronal population. On the other hand, the arcuate nucleus (ARC) metastin/kisspeptin neuronal population is considered to be involved in the regulation of tonic GnRH release. The ARC metastin/kisspeptin neurons show no sex difference in their expression, which is suppressed by gonadal steroids in both sexes. Thus, the ARC population of metastin/kisspeptin neurons is a target of estrogen negative feedback action on tonic GnRH release. The lactating rat model provided further evidence indicating that ARC in etastin/kisspeptin neurons are involved in GnRH pulse generation, because pulsatile release of luteinizing hormone (LH) is profoundly suppressed by suckling stimulus and the LH pulse suppression is well associated with the suppression of ARC metastin/kisspeptin and KISS-1 gene expression in lactating rats. (C) 2008 Elsevier Inc. All rights reserved.