Synthesis and biological evaluation of novel n-[3-(4-phenylpip-erazin-1-yl)-propyl]-carboxamide derivatives
Synthesis and biological evaluation of novel n-[3-(4-phenylpip-erazin-1-yl)-propyl]-carboxamide derivatives
复制标题
新型n-[3-(4-苯基哌拉嗪-1-基)-丙基]-甲酰胺衍生物的合成及生物学评价
DOI：
10.3184/174751911x556828
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发表时间：
2011-01-01
影响因子：
1.4
通讯作者：
Liu, Tao
中科院分区：
文献类型：
--
作者：
Weng, Zhiyong;Gao, Yanping;Liu, Tao
合成了一系列新的N-[3-（4-苯基哌嗪-1-基）-丙基]-甲酰胺衍生物，并研究了其治疗HIV的潜力。这些化合物是通过微波辅助合成的有效合成路线得到的。这些新化合物的结构经IR、（1）HNMR、MS和元素分析确证。还评价了化合物的细胞-细胞融合抑制活性。
A series of novel N-[3-(4-phenylpiperazin-1-yl)-propyl]-carboxamide derivatives were synthesised and studied for the potential treatment of HIV. These compounds were obtained through the efficient synthetic route that involved microwave assisted synthesis. These new compounds have been characterised by IR, (1)H NMR, MS and elemental analysis. The cell-cell fusion inhibitory activities of the compounds have also been evaluated.