New members of mammalian aquaporins: AQP10-AQP12.
New members of mammalian aquaporins: AQP10-AQP12.
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DOI：
10.1007/978-3-540-79885-9_13
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发表时间：
2009-01-01
影响因子：
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通讯作者：
Ishibashi, Kenichi
中科院分区：
文献类型：
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作者：
Ishibashi, Kenichi
哺乳动物水通道蛋白的13个成员已被确定。最初的10个成员（AQP-AQP 9）相对详细，并阐明了他们的作用。然而，最后三个成员，AQP 10-AQP 12，虽然在6年前被克隆，但其特征很差，对其作用知之甚少。在这篇综述中，我们将重点介绍这三种AQP。AQP 10是一种水甘油通道蛋白，而AQP 11和AQP 12属于一个新的亚家族，超水通道蛋白。这些水通道蛋白的敲除小鼠现在可用。AQP 11基因敲除小鼠具有显著的表型，即多囊性肾，这在肾脏上是致命的。另一方面，其他两人的缺席影响不大。在某些动物中，AQP 10甚至是假基因。本文综述了目前对这些水通道蛋白的认识，并希望能促进未来的研究。
Thirteen members of mammalian aquaporins have been identified. Initial ten members (AQP-AQP9) are relatively well detailed and their roles are clarified. However, the last three members, AQP10-AQP12, are poorly characterized and little is known about their roles though they were cloned 6 years ago. In this review, we focus on these three AQPs. AQP10 is an aquaglyceroporin while AQP11 and AQP12 belong to a new subfamily, superaquaporins. Knockout mice for these aquaporins are now available. The AQP11 null mouse has a remarkable phenotype, polycystic kidneys, which is neonatally fatal. On the other hand, the absence of the other two affected little. In some animals, AQP10 is even a pseudogene. This review summarizes the current knowledge on these AQPs and will hopefully stimulate future research on the subject.