A Neuroanatomical Signature for Schizophrenia Across Different Ethnic Groups.
A Neuroanatomical Signature for Schizophrenia Across Different Ethnic Groups.
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DOI：
10.1093/schbul/sbv109
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发表时间：
2015-11
影响因子：
6.6
通讯作者：
Mechelli A
中科院分区：
文献类型：
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作者：
Gong Q;Dazzan P;Scarpazza C;Kasai K;Hu X;Marques TR;Iwashiro N;Huang X;Murray RM;Koike S;David AS;Yamasue H;Lui S;Mechelli A
精神分裂症是一种致残的临床综合症，在世界各地都有发现。虽然这种疾病的发病率和临床表现受种族因素的强烈影响，但不同种族的患者是否表现出不同的脑缺陷尚不清楚。在这项多中心研究中，我们使用结构磁共振成像研究了126例首发精神分裂症患者的神经解剖学，这些患者来自4个不同种族的队列（白种人、非洲-加勒比人、日本人和中国人）。每个患者单独与相同种族、性别和年龄（±1岁）的健康对照配对。我们报道，与对照组相比，患者右侧前岛灰质体积减少（P < 0.05校正）；尽管在精神病理、抗精神病药物暴露和图像获取顺序上存在差异，但在所有4个种族中都检测到这种减少。这一发现为精神分裂症的神经解剖学特征提供了证据，这些特征在发病率和临床表现上超越了种族差异。根据现有文献，双相情感障碍、抑郁症、成瘾症、强迫症和焦虑症均涉及右前叶岛，我们推测这里报道的神经解剖缺陷可能代表了轴一障碍的一种跨诊断特征。
Schizophrenia is a disabling clinical syndrome found across the world. While the incidence and clinical expression of this illness are strongly influenced by ethnic factors, it is unclear whether patients from different ethnicities show distinct brain deficits. In this multicentre study, we used structural Magnetic Resonance Imaging to investigate neuroanatomy in 126 patients with first episode schizophrenia who came from 4 ethnically distinct cohorts (White Caucasians, African-Caribbeans, Japanese, and Chinese). Each patient was individually matched with a healthy control of the same ethnicity, gender, and age (±1 year). We report a reduction in the gray matter volume of the right anterior insula in patients relative to controls (P < .05 corrected); this reduction was detected in all 4 ethnic groups despite differences in psychopathology, exposure to antipsychotic medication and image acquisition sequence. This finding provides evidence for a neuroanatomical signature of schizophrenia expressed above and beyond ethnic variations in incidence and clinical expression. In light of the existing literature, implicating the right anterior insula in bipolar disorder, depression, addiction, obsessive-compulsive disorder, and anxiety, we speculate that the neuroanatomical deficit reported here may represent a transdiagnostic feature of Axis I disorders.