Reversible and irreversible changes of the stria vascularis. An evaluation of the effects of ethacrynic acid separately and in combination with atoxyl.
Reversible and irreversible changes of the stria vascularis. An evaluation of the effects of ethacrynic acid separately and in combination with atoxyl.
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DOI：
10.3109/00016487809121463
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发表时间：
1978
影响因子：
1.4
通讯作者：
M. Anniko
中科院分区：
文献类型：
--
作者：
M. Anniko
给药后耳蜗的形态学改变最初发生在基圈血管纹，边缘细胞的细胞内囊泡增多，中间细胞层细胞间和细胞内水肿。乙酸和甲氧基（单剂量）联合给药可对耳蜗毛细胞和血管纹造成不可逆的损伤，而分别以相同的低剂量给药则未引起毛细胞变性或血管纹的持续形态改变。由于乙丙酸引起的内淋巴分区渗透性的改变，使得先前已知的阿托酚进入耳蜗的渗透性增加，这可能导致阿托酚进入耳蜗的渗透性增加。
The morphological changes in the cochlea following administration of ethacrynic acid occur initially in the stria vascularis of the basal coils as an increased intracellular vesiculation of the marginal cells followed by inter- and intracellular oedema in the intermediate cell layer. The combined administration of ethacrynic acid and atoxyl (individual doses) can cause irreversible damage to the cochlear hair cells and the stria vascularis, while the administration of each of them separately in the same low dose did not cause hair cell degeneration or persistent morphological changes of the stria vascularis. An increased penetration of atoxyl into the cochlea is likely to occur due to the ethacrynic acid-induced changes in the permeability of the endolymphatic partition so that the earlier known penetration of atoxyl into the cochlea is increased.