HOST FACTORS AND BREAST-CANCER GROWTH-CHARACTERISTICS
HOST FACTORS AND BREAST-CANCER GROWTH-CHARACTERISTICS
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DOI：
10.1016/0959-8049(92)90477-j
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发表时间：
1992-01-01
影响因子：
8.4
通讯作者：
NOTTAGE, EM
中科院分区：
文献类型：
--
作者：
INGRAM, DM;ROBERTS, A;NOTTAGE, EM
乳腺癌的生长和扩散速度因患者而异。进行了一项观察性研究，以确定乳腺癌生长特征与各种宿主因素之间的可能关联，包括91例乳腺癌患者的人口统计学，人体测量学，激素和饮食变量。年龄增长与有利的生长特征相关，而既往扁桃体切除术与不利的生长特征相关。在人体测量变量中没有显著的相关性。对于绝经后妇女，雌二醇的生物利用度增加与有利的生长特征相关，而催乳素浓度增加与不利的生长特征相关。糖、纤维、水果和蔬菜以及维生素消费量的增加与有利的生长特性有关。当调整总能量摄入量时，脂肪（单不饱和和饱和）的消耗与不良特征相关。宿主环境可能在控制乳腺癌生长中发挥作用。特别是，与雌激素和孕激素受体状态的相关性表明营养素可能具有作为激素治疗患者生物反应调节剂的价值。这需要进一步研究以评估治疗潜力。
The rate of growth and spread of breast cancer varies considerably from patient to patient. An observational study was undertaken to identify possible associations between breast cancer growth characteristics and a wide variety of host factors, including demographic, anthropometric, hormonal and dietary variables in 91 patients with breast cancer. Increasing age was associated with favourable growth characteristics, while previous tonsillectomy was associated with adverse growth characteristics. There were no significant associations in anthropometric variables. For postmenopausal women, increasing bioavailability of oestradiol was associated with favourable growth characteristics, while increasing prolactin concentration was associated with adverse growth characteristics. Increasing consumption of sugar, fibre, fruit and vegetables and vitamins was associated with favourable growth characteristics. Consumption of fat (monounsaturated and saturated) was associated with adverse characteristics when adjustment was made for total energy intake. The host environment may play a role in the control of breast cancer growth. In particular, the associations with oestrogen and progesterone receptor status indicate that nutrients may be of value as biological response modifiers in patients having hormonal therapy. This requires further investigation to assess therapeutic potential.