Collapsin response mediator proteins (CRMPs) - Involvement in nervoust system development and adult neurodegenerative disorders
Collapsin response mediator proteins (CRMPs) - Involvement in nervoust system development and adult neurodegenerative disorders
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DOI：
10.1385/mn:28:1:51
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发表时间：
2003-08-01
影响因子：
5.1
通讯作者：
Honnorat, J
中科院分区：
文献类型：
--
作者：
Charrier, E;Reibel, S;Honnorat, J
胞浆蛋白反应介体蛋白（CRMP）家族的成员--五种胞质磷酸化蛋白--在整个脑发育过程中高度表达。第一个被克隆的成员，CRMP 2，被确定为一个细胞内信使所需的生长锥崩溃诱导semaphorin 3A（Sema 3A）。大量研究表明CRMPs的功能不仅仅局限于Sema 3A的信号转导。它们可能参与细胞凋亡/增殖、细胞迁移和分化中涉及的多种细胞和分子事件。在成人大脑中，CRMPs的表达显著下调。然而，它们仍然在保留其分化和可塑性能力的结构中表达，并且还在少突胶质细胞亚群（CRMP 2和CRMP 5）中表达。此外，CRMPs的表达在神经退行性疾病中改变，并且这些蛋白质可能在成人神经系统的生理病理学中具有关键重要性。
The members of the collapsin response mediator protein (CRMP) family-five cytosolic phosphoproteins-are highly expressed throughout brain development. The first member to be cloned, CRMP2, was identified as an intracellular messenger required for the growth cone-collapse induced by semaphorin 3A (Sema3A). A rapidly expanding body of study indicates that the functions of CRMPs are not solely limited to the signaling transduction of the Sema3A guidance cue. They are probably involved in multiple cellular and molecular events involved in apoptosis/proliferation, cell migration, and differentiation. In the adult brain, the expression of CRMPs is dramatically downregulated. However, they remain expressed in structures that retain their capacity for differentiation and plasticity and also in a subpopulation of oligodendrocytes (CRMP2 and CRMP5). Moreover, the expression of CRMPs is altered in neurodegenerative diseases, and these proteins may be of key importance in the physiopathology of the adult nervous system.