PROGRESSIVE IMPAIRMENT OF CSF BETA-EP LEVELS IN MIGRAINE SUFFERERS
PROGRESSIVE IMPAIRMENT OF CSF BETA-EP LEVELS IN MIGRAINE SUFFERERS
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DOI：
10.1016/0304-3959(84)90880-7
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发表时间：
1984-01-01
期刊：
影响因子：
7.4
通讯作者：
SAVOLDI, F
中科院分区：
文献类型：
--
作者：
GENAZZANI, AR;NAPPI, G;SAVOLDI, F
普通型偏头痛（CM）是一种进展性疾病，其特征在于发作次数的进行性增加和随之而来的自由期的减少，最终达到持续性偏头痛伴阵发性头痛（MIH）的状态。为了评估中枢前阿片皮质素相关肽在疾病发病机制中的作用，测定了β-阿片皮质素相关肽的CSF水平。促脂素（β- LPH），sbd.内啡肽（β-测定了2组随病情加重的偏头痛患者（CM和MIH）和健康对照组的EP）和ACTH。ACTH值在3组中相似，而β-在患有MIH的患者中，LPH水平显著较低（P < 0.005）（10.4 ± 0.05）。8.6 fmol/ml）高于CM患者（35.7 ± 0.01mmol/ml）。8.3)对照组（32.9 ±. 15.33）。β- EP水平与疾病的严重程度密切相关：与健康对照组相比，EP水平显著降低（86.1 ± 0.001）。37 fmol/ml）对CM患者的那些（38.5 ±. 3.5; P < 0.005），并进一步显著下降（P < 0.01）至MIH患者中发现的最低水平（14.8 ± 0.01）。9.8）。偏头痛的进行性演变伴随着CSF中β-谷氨酰胺水平的进行性损害。EP.非器质性中枢疼痛与负责CSF中β-CSF含量的神经元的活性降低有关。EP.
Common migraine (CM) is an evolutive disease characterized by a progressive increase in the number of attacks and a consequent reduction in the free periods, eventually reaching a state of continuous migraine with interparoxysmal headache (MIH). To evaluate the role of central pro-opiocortin-related peptides in the pathogenesis of the disease, CSF levels of .beta.-lipotropin (.beta.-LPH), .sbd.endorphin (.beta.-EP) and ACTH were measured in 2 groups of migraine sufferers with increasing severity of the disease (CM and MIH), and in healthy controls. ACTH values were similar in the 3 groups, while .beta.-LPH levels were significantly lower (P < 0.005) in patients affected by MIH (10.4 .+-. 8.6 fmol/ml) than in patients with CM (35.7 .+-. 8.3) and in controls (32.9 .+-. 15.33). .beta.-EP levels were closely correlated with the severity of the disease: they decreased significantly from those found in healthy controls (86.1 .+-. 37 fmol/ml) to those of CM sufferers (38.5 .+-. 3.5; P < 0.005) and showed a further significant fall (P < 0.01) to the lowest levels which were found in MIH patients (14.8 .+-. 9.8). The progressive evolution of migraine is concomitant with a progressive impairment in the CSF levels of .beta.-EP. Non-organic central pain is related to a reduced activity of the neurons responsible for the CSF content of .beta.-EP.