Prostate volume and adverse prostate cancer features: Fact not artifact
Prostate volume and adverse prostate cancer features: Fact not artifact
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DOI：
10.1016/j.ejca.2007.09.022
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发表时间：
2007-12-01
影响因子：
8.4
通讯作者：
Karakiewicz, Pierre I.
中科院分区：
文献类型：
--
作者：
Briyanti, Alberto;Chun, Felix K. -H.;Karakiewicz, Pierre I.
目的：最近的一项前列腺癌非那雄胺化学预防试验显示，在接触非那雄胺的男性中，六分仪活检检测出高级别前列腺癌（HGPCa）的比例较高，这些男性的前列腺明显小于对照组。我们在一个大型 (n = 3412) 单中心根治性前列腺切除术队列中研究了前列腺大小与前列腺癌分级和分期之间的关联，该队列未接受任何形式的激素操作。方法：使用 Logistic 回归模型。结果：小前列腺与活检和根治性前列腺切除术时较高的 HGPCa 率相关（均 p < 0.001），囊外扩展率较高（p < 0.001），精液囊外延伸率较高。在考虑了年龄、PSA、临床分期和手术年份后，囊泡侵犯 (p < 0.001) 且肿瘤体积 > 3.4cc。 结论：我们的研究结果表明，位于小腺体的前列腺癌基本上比位于大腺体的前列腺癌更具侵袭性。因此，前列腺癌的检测和治疗策略应考虑前列腺体积。 (c) 2007 Elsevier Ltd. 保留所有权利。
Purpose: A recent prostate cancer finasteride chemoprevention trial showed a higher rate of sextant biopsy-detected high grade prostate cancer (HGPCa) in finasteride exposed men, whose prostates were significantly smaller than those of controls. We investigated the association between prostate size and prostate cancer grade and stage in a large (n = 3412) single center radical prostatectomy cohort, which was unexposed to any form of hormonal manipulation.Methods: Logistic regression models were used.Results: Small prostates were associated with higher rate of HGPCa at biopsy and at radical prostatectomy (both p < 0.001), with higher rate of extracapsular extension (p < 0.001), seminal vesicle invasion (p < 0.001) and with tumor volume > 3.4cc, after accounting for age, PSA, clinical stage and year of surgery.Conclusions: Our findings demonstrate that prostate cancers located in small glands are fundamentally more aggressive than those located within larger glands. in consequence, prostate cancer detection and treatment strategies should account for prostate volume. (c) 2007 Elsevier Ltd. All rights reserved.