Automatic mapping of atrial fiber orientations for patient-specific modeling of cardiac electromechanics using image registration
Automatic mapping of atrial fiber orientations for patient-specific modeling of cardiac electromechanics using image registration
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DOI：
10.1002/cnm.3190
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发表时间：
2019-06-01
影响因子：
2.1
通讯作者：
Wall, Wolfgang A.
中科院分区：
文献类型：
--
作者：
Hoermann, Julia M.;Pfaller, Martin R.;Wall, Wolfgang A.
适当的局部纤维结构的知识是必要的，以模拟患者特定的人体心脏的机电。然而，目前还不可能可靠地测量体内纤维方向，特别是在人类心房中。因此，我们提出了一种方法，定义在任意形状的心房使用图像配准和重定向方法的基础上，从详细的组织学观察预定义的纤维图谱心房的纤维结构。因此，可以在自动化的、时间有效的过程中以每个新的患者特定几何形状生成详细的纤维族。我们证明了良好的性能的图像配准和纤维的定义上10个不同形状的人类心房。此外，我们还发现寰椎心房电生理激活模式的特征也出现在患者的心房中。我们得出类似的结论耦合机电血液动力学计算。
Knowledge of appropriate local fiber architecture is necessary to simulate patient-specific electromechanics in the human heart. However, it is not yet possible to reliably measure in vivo fiber directions especially in human atria. Thus, we present a method that defines the fiber architecture in arbitrarily shaped atria using image registration and reorientation methods based on atlas atria with fibers predefined from detailed histological observations. Thereby, it is possible to generate detailed fiber families in every new patient-specific geometry in an automated, time-efficient process. We demonstrate the good performance of the image registration and fiber definition on 10 differently shaped human atria. Additionally, we show that characteristics of the electrophysiological activation pattern that appear in the atlas atria also appear in the patients' atria. We arrive to analogous conclusions for coupled electro-mechano-hemodynamical computations.