HORMONE PROFILES FOR PROGESTERONE, ESTRADIOL, PROLACTIN, PLASMA-RENIN ACTIVITY, ALDOSTERONE AND CORTICOSTERONE DURING PREGNANCY AND PSEUDOPREGNANCY IN 2 STRAINS OF RAT - CORRELATION WITH RENAL STUDIES
HORMONE PROFILES FOR PROGESTERONE, ESTRADIOL, PROLACTIN, PLASMA-RENIN ACTIVITY, ALDOSTERONE AND CORTICOSTERONE DURING PREGNANCY AND PSEUDOPREGNANCY IN 2 STRAINS OF RAT - CORRELATION WITH RENAL STUDIES
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DOI：
10.1677/joe.0.1130435
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发表时间：
1987-06-01
影响因子：
4
通讯作者：
MILNE, CM
中科院分区：
文献类型：
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作者：
GARLAND, HO;ATHERTON, JC;MILNE, CM
从Sprague-Dawley（SD）大鼠和慕尼黑Wistar（MW）品系大鼠在整个妊娠和假妊娠期间采集血浆样品。用放射免疫法测定两品系大鼠孕酮、雌二醇、催乳素、血浆肾素活性（PRA）、醛固酮和皮质酮的浓度，以建立两品系大鼠的激素谱。循环孕酮浓度在这两个品系的大鼠在怀孕期间显着高于处女对照组，除了在SD组的术语。假性孕激素模式与妊娠前半期相似。雌二醇浓度相似，或低于，在整个假孕和怀孕的前2周，在两个品系的大鼠处女对照。类固醇浓度增加，只看到在怀孕组接近足月。在SD大鼠中，最高催乳素浓度在妊娠前半期和假妊娠期以及妊娠组的足月时明显。怀孕的MW大鼠表现出不同的配置文件，这种激素，在整个怀孕期间，除了在任期低水平。在所有组中，PRA在第9天上升至峰值，并下降至第16天。妊娠SD大鼠在足月时也表现出显著增加。醛固酮浓度显着增加，在怀孕的几个阶段，在两个品系的大鼠，特别是在妊娠的后半段。假孕动物显示出不同的激素谱，直到第16天记录到较低浓度时才出现显著变化。除了怀孕的大鼠在足月时皮质酮浓度下降外，循环中皮质酮浓度几乎没有变化。这些研究结果进行了讨论，在已知的肾脏变化的妊娠和假性妊娠。
Plasma samples were obtained throughout pregnancy and pseudopregnancy from Sprague-Dawley (SD) rats and during pregnancy from rats of the Munich Wistar (MW) strain. The concentrations of progesterone, oestradiol, prolactin, plasma renin activity (PRA), aldosterone and corticosterone were measured by radioimmunoassay to establish hormonal profiles in the two strains of rat. Circulating progesterone concentrations in both strains of rat were significantly higher during pregnancy than in virgin controls, except at term in the SD group. The hormonal pattern for pseudopregnancy was similar to that of the first half of pregnancy. Oestradiol concentrations were similar to, or lower than, those in virgin controls throughout pseudopregnancy and for the first 2 weeks of pregnancy in both strains of rat. Increased concentrations of steroid were seen only in the pregnant groups towards term. In SD rats, highest prolactin concentrations were apparent during the first half of pregnancy and pseudopregnancy, and at term in the pregnant group. Pregnant MW rats showed a different profile for this hormone, with low levels throughout pregnancy except at term. In all groups PRA rose to a peak at day 9 and decreased to day 16. Pregnant SD rats also showed a significant increase at term. Aldosterone concentrations were significantly increased at several stages of pregnancy in both strains of rat, particularly during the second half of gestation. Pseudopregnant animals showed a different hormone profile, with no significant changes until day 16 when lower concentrations were recorded. There was little variation in the circulating corticosterone concentration except in pregnant rats at term when levels fell. These findings are discussed in relation to the known renal changes of pregnancy and pseudopregnancy.