The relation between the growth patterns of gastric carcinoma and the expression of hepatocyte growth factor receptor (c-met), autocrine motility factor receptor, and urokinase-type plasminogen activator receptor
The relation between the growth patterns of gastric carcinoma and the expression of hepatocyte growth factor receptor (c-met), autocrine motility factor receptor, and urokinase-type plasminogen activator receptor
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DOI：
10.1002/(sici)1097-0142(19980601)82:11
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发表时间：
1998-06-01
期刊：
影响因子：
6.2
通讯作者：
Watanabe, H
中科院分区：
文献类型：
--
作者：
Taniguchi, K;Yonemura, Y;Watanabe, H
背景资料。肝细胞生长因子受体(c-MET)、自分泌运动因子受体(AMFR)和尿激酶型纤溶酶原激活剂受体(UPAR)在肿瘤细胞的迁移、侵袭和转移中起重要作用。方法采用免疫组织化学方法，对102例胃癌石蜡包埋标本中c-met、AMFR和uPAR的表达与临床病理参数的关系进行研究。结果：102例胃癌中，43例(42%)c-met过度表达，41例(40%)AMFR和38例(37%)uPAR表达阳性。肉眼观察发现，在32例早期胃癌中1例(3%)表达，29例局限性癌(Borrmann 1、2型)中0例(0%)，41例浸润性癌(Borrmann 3、4型)中16例(39%)表达。Borrmann 4型胃癌中三种基因同时表达的发生率(68%，13/19)显著高于其他肉眼类型(P<；0.01)。这些基因的过度表达也与淋巴结转移和腹膜扩散密切相关。此外，三种基因同时过表达与淋巴管侵袭阳性和浸润型有关。同时表达这三种基因的肿瘤患者的预后比只表达其中一种或两种基因的肿瘤患者要差得多。此外，c-Met、AMFR和uPAR的表达与胃癌的预后密切相关，Cox比例风险模型将其作为独立的预后因素之一。结论c-met、AMFR和uPAR的表达模式可能与胃癌的进展、侵袭以及患者的预后密切相关。Borrmann 4型胃癌的特点是这三个基因同时表达。(C)1998年美国癌症协会。
BACKGROUND. Hepatocyte growth factor receptor (c-met), autocrine motility factor receptor (AMFR), and urokinase-type plasminogen activator receptor (uPAR) are known to play important roles in tumor cell migration, invasion, and metastasis. The authors studied the relation between the expression patterns of these genes and the growth patterns of human gastric carcinoma.METHODS. The relation between the expression of c-met, AMFR, and uPAR and clinicopathologic parameters was studied using immunohistochemical preparations from 102 paraffin embedded primary gastric carcinomas.RESULTS. Of 102 cases, 43 (42%) had overexpression of c-met, and AMFR and uPAR immunoreactivity was observed in 41 cases (40%) and 38 cases (37%), respectively. Macroscopic examination revealed that all three genes were expressed in 1 (3%) of 32 early stage gastric carcinomas, 0 (0%) of 29 localized carcinomas (Borrmann types 1 and 2), and 16 (39%) of 41 infiltrating carcinomas (Borrmann types 3 and 4). In particular, the incidence (68%, 13 of 19 cases) of simultaneous expression of the three genes was significantly higher in Borrmann type 4 gastric carcinoma than in the other macroscopic types (P < 0.01). The overexpression of these genes was also closely associated with lymph node metastasis and peritoneal dissemination. In addition, the simultaneous overexpression of the three genes was associated with positive lymphatic vessel invasion and infiltrating type. Patients with tumors that simultaneously expressed all three genes had significantly poorer prognoses than those with tumors expressing only one or two of the genes. Furthermore, the number of genes expressed was closely related to the prognosis, and the Cox proportional hazards model identified this as one of the independent prognostic factors.CONCLUSIONS. These results suggest that the expression patterns of c-met, AMFR, and uPAR may be closely associated with the progression and invasion of gastric carcinoma as well as the prognoses of the patients. Borrmann type 4 gastric carcinoma is characterized by the diverse and simultaneous expression of these three genes. (C) 1998 American Cancer Society.