Modeling flow in collecting lymphatic vessels: one-dimensional flow through a series of contractile elements
Modeling flow in collecting lymphatic vessels: one-dimensional flow through a series of contractile elements
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DOI：
10.1152/ajpheart.00004.2008
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发表时间：
2008-07-01
影响因子：
4.8
通讯作者：
Winlove, C. P.
中科院分区：
文献类型：
--
作者：
Macdonald, A. J.;Arkill, K. P.;Winlove, C. P.
淋巴系统由一系列元素组成，淋巴管由瓣膜隔开，并具有活动的、可收缩的壁，将收集在末端淋巴管中的间质液体泵回主循环。尽管它很重要，但关于淋巴系统的流体动力学的信息却很匮乏。在这篇文章中，我们描述了旨在阐明单个淋巴管的生物力学特性的相关实验和计算工作。我们测量了离体牛收集淋巴管的静态和动态力学性质，并建立了流体流动/壁面运动耦合的一维计算模型。该计算模型能够使用一个简单的收缩函数来再现真实血管的泵送行为，该收缩函数产生沿流动的逆行方向传播的快速收缩脉冲。
The lymphatic system comprises a series of elements, lymphangions, separated by valves and possessed of active, contractile walls to pump interstitial fluid from its collection in the terminal lymphatics back to the main circulation. Despite its importance, there is a dearth of information on the fluid dynamics of the lymphatic system. In this article, we describe linked experimental and computational work aimed at elucidating the biomechanical properties of the individual lymphangions. We measure the static and dynamic mechanical properties of excised bovine collecting lymphatics and develop a one-dimensional computational model of the coupled fluid flow/wall motion. The computational model is able to reproduce the pumping behavior of the real vessel using a simple contraction function producing fast contraction pulses traveling in the retrograde direction to the flow.